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Molecular functions of microRNAs in colorectal cancer: recent roles in proliferation, angiogenesis, apoptosis, and chemoresistance.
Naunyn Schmiedebergs Arch Pharmacol
August 2024
Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.
Article Synopsis
- - MiRNAs are small non-coding RNA molecules that regulate gene expression by binding to mRNA, leading to its degradation or repression, with their biogenesis involving several detailed steps such as transcription and processing.
- - Colorectal cancer, a common and serious disease with low early diagnosis rates and high metastasis, is influenced by genetic and epigenetic factors, especially miRNAs, which can act as tumor suppressors or oncogenes depending on their target genes.
- - MiRNAs show promise as biomarkers for colorectal cancer due to their stability and ease of detection in body fluids, enabling differentiation between cancer patients and healthy individuals, predicting cancer stage, and monitoring responses to treatment.
Functional diversity of nanohaloarchaea within xylan-degrading consortia.
Front Microbiol
May 2023
Extreme Microbiology, Biotechnology and Astrobiology Group, Institute of Polar Research, ISP-CNR, Messina, Italy.
Extremely halophilic representatives of the phylum Nanohaloarchaeota (members of the DPANN superphyla) are obligately associated with extremely halophilic archaea of the phylum (according to the GTDB taxonomy). Using culture-independent molecular techniques, their presence in various hypersaline ecosystems around the world has been confirmed over the past decade. However, the vast majority of nanohaloarchaea remain uncultivated, and thus their metabolic capabilities and ecophysiology are currently poorly understood.
View Article and Find Full Text PDFExpected value of artificial intelligence in gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.
Endoscopy
December 2022
Department of Gastroenterology, Porto Comprehensive Cancer Center, and RISE@CI-IPOP (Health Research Network), Porto, Portugal.
This ESGE Position Statement defines the expected value of artificial intelligence (AI) for the diagnosis and management of gastrointestinal neoplasia within the framework of the performance measures already defined by ESGE. This is based on the clinical relevance of the expected task and the preliminary evidence regarding artificial intelligence in artificial or clinical settings. MAIN RECOMMENDATIONS:: (1) For acceptance of AI in assessment of completeness of upper GI endoscopy, the adequate level of mucosal inspection with AI should be comparable to that assessed by experienced endoscopists.
View Article and Find Full Text PDFDefinition of competence standards for optical diagnosis of diminutive colorectal polyps: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.
Endoscopy
January 2022
Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, location AMC, University of Amsterdam, Amsterdam, The Netherlands.
BACKGROUND : The European Society of Gastrointestinal Endoscopy (ESGE) has developed a core curriculum for high quality optical diagnosis training for practice across Europe. The development of easy-to-measure competence standards for optical diagnosis can optimize clinical decision-making in endoscopy. This manuscript represents an official Position Statement of the ESGE aiming to define simple, safe, and easy-to-measure competence standards for endoscopists and artificial intelligence systems performing optical diagnosis of diminutive colorectal polyps (1 - 5 mm).
View Article and Find Full Text PDFCultivation of a vampire: 'Candidatus Absconditicoccus praedator'.
Environ Microbiol
January 2022
Winogradsky Institute of Microbiology, Research Centre of Biotechnology, Russian Academy of Sciences, Moscow, Russia.
Halorhodospira halophila, one of the most-xerophilic halophiles, inhabits biophysically stressful and energetically expensive, salt-saturated alkaline brines. Here, we report an additional stress factor that is biotic: a diminutive Candidate-Phyla-Radiation bacterium, that we named 'Ca. Absconditicoccus praedator' M39-6, which predates H.
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