Background: The renin angiotensin system (RAS) promotes vasoconstriction. Expression of RAS is induced by different factors.
Methods: In this study, forebrain sections of hamster brains were studied by immunohistochemical methods to determine the location of renin-positive and angiotensin II receptor-positive cells. The brain sections were obtained from diethylstilbesterol- (DES-) treated hamsters, adult non-DES-treated hamsters, elderly non-DES-treated hamsters, neonatal hamsters, and 15-day fetal hamsters. Circulating renin activity was determined for all but the neonatal and 15-day fetal hamsters.
Results: Renin-positive and angiotensin II receptor-positive vascular smooth muscle cells were observed in DES-treated hamsters. No positive cells were observed in neonatal, 15-day fetal, and adult non-DES-treated hamsters. Some expression was observed in elderly hamsters.
Conclusions: Therefore, focal expression of the renin angiotensin system in brain vasculature was induced by the synthetic estrogen DES.
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