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Myelodysplastic syndromes (MDS) are age-related diseases characterized by bone marrow (BM) dysfunction and an increased risk of developing acute leukemia. While there is growing evidence highlighting the crucial role of the BM microenvironment (BMME) in MDS, the specific influence of inflammation on BMME changes, as well as the potential benefits of targeting cytokines therapeutically, remain to be elucidated. We previously found interleukin-1 (IL-1) to be a driver of aging phenotypes of BMME and hematopoietic stem and progenitor cells (HSPCs).
View Article and Find Full Text PDFExploring Mental Health Issues and Priorities in Indonesia Through Qualitative Expert Consensus.
Clin Pract Epidemiol Ment Health
November 2024
Health Collaborative Center (HCC), Jakarta, Indonesia.
Background: Mental health well-being is a fundamental human right. However, mental health awareness is not yet considered as a main priority for the government and public in Indonesia. Thus, there is an urgent need for Indonesians to fully comprehend the importance of raising mental health awareness.
View Article and Find Full Text PDFClimate-Driven Escalation of Global PM Health Burden from Wildland Fires.
Environ Sci Technol
January 2025
College of Urban and Environmental Sciences, Peking University, Beijing 100871, China.
Wildland fires constitute a major source of ambient fine particulate matter (PM), significantly impacting air quality and public health. As the climate becomes warmer and drier, fire frequency is projected to rise, yet how the associated health impacts of fire-sourced PM (FPM) respond to climate change remains vague. In this study, we modeled the global concentration and associated premature deaths of FPM over the past two decades.
View Article and Find Full Text PDFBackground: Critical care nurses are vulnerable to depression, which not only lead to poor well-being and increased turnover intention, but also affect their working performances and organizational productivity as well. Work related factors are important drivers of depressive symptoms. However, the non-liner and multi-directional relationships between job demands-resources and depressive symptoms in critical care nurses has not been adequately analyzed.
View Article and Find Full Text PDFGenetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis.
BMC Med
January 2025
Department of Cardiothoracic Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Background: Current research underscores the need to better understand the pathogenic mechanisms and treatment strategies for idiopathic pulmonary fibrosis (IPF). This study aimed to identify key targets involved in the progression of IPF.
Methods: We employed Mendelian randomization (MR) with three genome-wide association studies and four quantitative trait loci datasets to identify key driver genes for IPF.
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