Data on peroral application of new peptide origin immunocorrector from nervous tissue of hydrobionts are cited. It has been established that immunological gangliin activity, perorally introduced, is close to that being applied parenterally. This drug comprises a soft immunocorrector that is expressed by humoral and cellular factor strengthening of immunity, increasing induces of phagocynosis of PMNC and sells SMPh. Peroral gangliin introduction protects 50-60% of mice from fatal coli-infection. Gangliin availability to be taken perorally opens the door to its wide application as food addition.
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Ann Med
December 2025
Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China.
A high recurrence rate is undesirable after treatment of common bile duct (CBD) stones. A major risk factor identified for recurrence is that invasive techniques, including surgical or endoscopic treatments, will impair the biliary tract system either by direct incision of the CBD or by cutting or dilating the ampulla of Vater. During endoscopic treatment, two main assisted methods for lithotomy, sphincterotomy and papillary balloon dilation, can result in different degrees of damage to the structure and function of the sphincter of Oddi (SO), contributing to slowing of biliary excretion, cholestasis, biliary bacterial infection, and promotion of bile duct stone recurrence.
View Article and Find Full Text PDFInt J Mol Sci
October 2024
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia.
Mitochondrial damage and associated oxidative stress are considered to be major contributory factors in cardiac pathology. One of the most potent naturally occurring antioxidants is taxifolin, especially in its water-soluble form. Herein, the effect of a 14-day course of the peroral application of the water-soluble taxifolin (aqTAX, 15 mg/kg of body weight) on the progression of ultrastructural and functional disorders in mitochondria and the heart's electrical activity in a rat model of myocardial injury induced with isoprenaline (ISO, 150 mg/kg/day for two consecutive days, ) was studied.
View Article and Find Full Text PDFGastroenterol Clin North Am
December 2024
Division of Gastroenterology and Hepatology, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA. Electronic address:
Diagnostics (Basel)
September 2024
Gastroenterology and Gastrointestinal Endoscopy Division, IRCCS San Raffaele Institute, Via Olgettina 60, 20132 Milan, Italy.
Asian J Surg
September 2024
Department of Biliopancreatic Endoscopic Surgery, Retrograde The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. Electronic address:
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