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Antibiotic-perturbed microbiota and the role of probiotics.
Nat Rev Gastroenterol Hepatol
December 2024
International Scientific Association for Probiotics and Prebiotics, Consulting Scientific Advisor, Centennial, CO, USA.
Article Synopsis
- * Clinical studies show probiotics might help reduce side effects like diarrhea from Clostridioides difficile, yet there's no direct evidence connecting these outcomes to microbiota protection.
- * The review discusses the complexities of studying microbiota restoration, including the challenges of defining a "normal" microbiota, varying measurement methods, and individual differences, while suggesting future research directions.
Molecular epidemiology and antimicrobial resistance in Clostridioides difficile strains isolated from children and adolescents in a tertiary referral pediatric hospital in Fortaleza, Brazil.
Braz J Infect Dis
June 2024
Universidade Federal do Ceará, Núcleo de Microscopia e Processamento de Imagens (NEMPI), Departamento de Morfologia Fortaleza, CE, Brazil.
Article Synopsis
- - The study investigated the prevalence and characteristics of C. difficile infections in children and adolescents with diarrhea in northeastern Brazil, revealing a significant infection rate of 30.4% among samples tested.
- - A total of four toxigenic strains were identified, with most samples showing susceptibility to metronidazole and vancomycin, while diarrhea associated with these infections lasted an average of 11 days and was often severe.
- - The research indicates that comorbid chronic diseases were key risk factors for these infections, underscoring the need for further awareness and understanding of C. difficile's impact on pediatric health in the region.
Implementing the WHO AWaRe antibiotic book guidance in lower-resource settings: the case of the Lao PDR.
JAC Antimicrob Resist
February 2024
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Mahosot Hospital, Vientiane, Lao PDR.
In 2022, WHO released the WHO AWaRe (Access, Watch, Reserve) antibiotic book to promote the rational use of antibiotics. Here, we review the AWaRe antibiotic book from the perspective of implementation in low-resource settings, using the Lao PDR (Laos) as a case study. Not all recommendations in the AWaRe antibiotic book match the epidemiology of infectious diseases and antimicrobial susceptibility patterns in Laos and other low- and middle-income countries (LMICs), e.
View Article and Find Full Text PDFA Rare Case of Polymerase Chain Reaction-Negative Severe Clostridioides difficile Infection.
Cureus
December 2023
Gastroenterology, Saint Michael's Medical Center, Newark, USA.
Accurately diagnosing infection (CDI) is crucial for effective patient management. A misdiagnosis poses risks to patients, leads to treatment delays, and contributes to infection transmission in healthcare settings. While using polymerase chain reaction (PCR) to amplify the toxin B gene is a sensitive method for detecting toxigenic , there is still a risk of false-negative results.
View Article and Find Full Text PDFAzithromycin Treatment for Acne Vulgaris: A Case Report on the Risk of Clostridioides difficile Infection.
Am J Case Rep
November 2023
Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
BACKGROUND Clostridium difficile (C. difficile) is a gram-positive, anaerobic, spore-forming bacillus. It can lead to pseudomembranous colitis characterized by electrolyte disturbances, toxic megacolon, and septic shock.
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