The aim of this paper was to present the use of Cefamandole as one of the elements in perioperative prophylactics in total hip replacement. One hundred patients operated between 1993 and 1995 were followed-up for mean 13.5 months. There were 33 males and 67 females, mean age was 61.4 years. Cefamandole was administered according to fixed protocol for three days (first dose along with premedication). Mono-antibiotic therapy was sufficient in most cases. No septic complication occurred, no side-effects of Cefamandole were recorded. The patients are still being followed-up. Results achieved resemble these from the literature so conclusion can be made, that Cefamandole is safe and efficient drug for peri-operative prophylactics in total hip replacement.
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