The capacity of CFU-S-11, which formed colonies in the spleen on day 11 after transplantation to an irradiated recipient for self-maintenance, was studied. The indices for self-renewal of individual CFU-S from the spleen, bone marrow, and peripheral blood were compared in the same sexually mature donor mice by retransplanting the colonies isolated from the spleen parenchyma to secondary recipients. The number of secondary CFU-S-11 per primary CFU-S-11 originating from the liver hardly differed from that originating from the peripheral blood, but is almost twice less than for the bone marrow CFU-S-11. The conclusion was drawn that compartment CFU-S of the liver of adult animals contains the cells migrating from blood flow, which, apparently, are not dormant embryonic cells.
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