Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an extended and hitherto undescribed properties for clodronate/biphosphonates in prevention and treatment of tissue degradation in both bone and soft tissue destructive diseases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s002239900295 | DOI Listing |
Publication Analysis
Top Keywords
inhibition matrix
4
matrix metalloproteinase-1
4
metalloproteinase-1 dichloromethylene
4
dichloromethylene bisphosphonate
4
bisphosphonate clodronate
4
clodronate interstitial
4
interstitial collagenase
4
collagenase human
4
human jaw
4
jaw cyst
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!