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Stress and obesity signaling converge on CREB phosphorylation to promote pancreatic cancer.
Mol Cancer Res
December 2024
University of California, Los Angeles, Los Angeles, CA, United States.
One of the deadliest types of cancer is pancreatic ductal adenocarcinoma (PDAC). Chronic stress and obesity are recognized as risk factors for PDAC. We hypothesized that the combination of stress and obesity strongly promotes pancreatic cancer development and growth.
View Article and Find Full Text PDFWhole-body mass spectrometry imaging reveals the systemic metabolic disorder and catecholamines biosynthesis alteration on heart-gut axis in heart failure rat.
J Adv Res
September 2024
Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China. Electronic address:
Article Synopsis
- Heart failure (HF) is identified as a complex systemic metabolic disorder affecting multiple organs, and whole-body mass spectrometry imaging (MSI) is utilized to study the metabolic changes linked to HF.
- The study focuses on exploring metabolic disorders, specifically alterations in catecholamine biosynthesis along the heart-gut axis after HF, using a combination of imaging and biochemical methods on rat tissues.
- Findings reveal significant changes in catecholamine levels in various organs, with excessive norepinephrine contributing to cardio-intestinal injury; this effect can be mitigated by metoprolol treatment, highlighting a potential therapeutic angle.
Sympathetic Activation Promotes Cardiomyocyte Apoptosis in a Rabbit Susceptibility Model of Hyperthyroidism-Induced Atrial Fibrillation via the p38 MAPK Signaling Pathway.
Crit Rev Eukaryot Gene Expr
May 2023
Fuwai Yunnan Cardiovascular Hospital, Kunming 650102, Yunnan, China.
Excess thyroid hormone secretion can cause endocrine metabolic disorders, which can lead to cardiovascular diseases, including heart enlargement, atrial fibrillation (AF), and heart failure. The present study investigated the molecular mechanisms of hyperthyroidism-induced AF. A rabbit susceptibility model of hyperthyroidism-induced AF was constructed, and metoprolol treatment was administered.
View Article and Find Full Text PDFUpregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic Response.
Cells
August 2022
Institute of Cardiovascular Sciences & Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
The activation of phospholipase C (PLC) is thought to have a key role in the cardiomyocyte response to several different hypertrophic agents such as norepinephrine, angiotensin II and endothelin-1. PLC activity results in the generation of diacylglycerol and inositol trisphosphate, which are downstream signal transducers for the expression of fetal genes, increased protein synthesis, and subsequent cardiomyocyte growth. In this article, we describe the signal transduction elements that regulate PLC gene expression.
View Article and Find Full Text PDFAlpha1B-adreneroceptor is involved in norepinephrine-induced pulmonary artery smooth muscle cell proliferation via p38 signaling.
Eur J Pharmacol
September 2022
College of Basic Medical Sciences, Harbin Medical University (Daqing), Daqing, 163319, PR China. Electronic address:
The higher norepinephrine (NE) concentration induced by sympathetic nerve hyperactivation participated in pulmonary artery smooth muscle cells (PASMCs) over-proliferation and led to pulmonary vascular remodeling (PVR), which played an important role in pulmonary artery hypertension (PAH). However, the underlying mechanism by which NE induced PASMCs proliferation had not been fully elucidated. In the present study, we found that prazosin, the inhibitor of α-AR, reversed hypoxia-induced changes in pulmonary circulatory function which were analyzed by echocardiography to measure pulmonary artery acceleration time (PAT) and pulmonary arterial velocity time integral (PAVTI) and right heart catheterization to test right ventricular systolic pressure (RVSP), respectively.
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