AI Article Synopsis
- The study analyzed the tat1 exon and TAR regions in HIV-1 from long-term nonprogressors and progressing patients to see how these genetic factors affect disease progression.
- Most of the tat1 alleles and promoter/TAR regions were found to be normal and had similar activity levels in tests.
- Some mutations and variations were noted, particularly in one nonprogressor where a key binding site was altered, but overall, issues with promoter/TAR regions and tat1 were not common, indicating that different progression rates are not typically linked to changes in these areas.
Article Abstract
Different rates of disease progression may be associated with different human immunodeficiency virus type 1 (HIV-1) promoter and/or transactivator activities. We therefore analyzed the sequences and activities of the first exon of Tat, tat1, and the promoter/trans-acting responsive (TAR) regions amplified directly from peripheral blood mononuclear cells obtained from five long-term nonprogressors and eight progressing HIV-1-infected individuals. The majority of tat1 alleles and promoter/TAR regions from all patients were intact and showed comparable activities in transient reporter assays. A substantial number of point mutations and some length variations were observed in the promoter/TAR region. In a single nonprogressor, the Sp1 binding site 3 was consistently altered and the transcriptional activity in the presence of Tat was diminished. Some LTR clones from a rapid progressor contained a fourth Sp1 binding site, which was associated with an elevated basal promoter activity. These data suggest that defects in the promoter/TAR region or tat1 are rare and that different promoter/transactivator activities are not commonly associated with different progression rates.
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| http://dx.doi.org/10.1006/viro.1997.8586 | DOI Listing |
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