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Dosing optimisation of intravenous lidocaine in patients with class 1-3 obesity by population pharmacokinetic analysis.
Anaesthesia
January 2025
Department of Anaesthesia and Perioperative Medicine, The Royal Brisbane and Women's Hospital, Brisbane, Australia.
Article Synopsis
- The study focused on developing an optimized lidocaine dosing regimen for obese patients during surgery, highlighting the need for more effective pain management.
- Researchers gathered data from 30 patients, measuring plasma levels of lidocaine and its metabolites to create a pharmacokinetic model.
- The findings suggested that current dosing was often inadequate, but an adjusted regimen could improve the likelihood of reaching therapeutic drug concentrations.
A case of a lidocaine intoxication of a 12 week old boy due to a circumcision in a domestic setting - clinical, toxicological and forensic aspects.
Forensic Sci Med Pathol
August 2024
Institute of Legal Medicine, Department of Forensic Toxicology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Köln, Germany.
Lidocaine is a local anaesthetic commonly used during circumcision for dorsal penile nerve block (DPNB). We describe a case of a 12-week-old infant who presented generalized seizures due to local anesthetic systemic toxicity after Lidocaine administration for circumcision in a non-hospital setting. Serum concentrations of Lidocaine (16.
View Article and Find Full Text PDFPharmacokinetics and metabolism of lidocaine HCl 2% with epinephrine in horses following a palmar digital nerve block.
BMC Vet Res
October 2023
School of Veterinary Medicine, University of California, Davis, CA, USA.
Background: Lidocaine is a local anesthetic that is sometimes administered in combination with epinephrine. The addition of epinephrine increases the time lidocaine remains at the site of administration, thus prolonging the duration of effect. Due to their potential to prevent the visual detection of lameness, the administration of local anesthetics is strictly regulated in performance and racehorses.
View Article and Find Full Text PDFLidocaine Intraoperative Infusion Pharmacokinetics during Partial Hepatectomy for Living Liver Donation.
Anesthesiology
January 2023
Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado.
Background: Postoperative pain associated with open partial hepatectomy can be intense and persistent. The multimodal approach used to lessen this problem includes an intraoperative intravenous infusion of lidocaine hydrochloride. Decreased hepatic metabolism after resection raises concerns about safe lidocaine dosing in this patient population.
View Article and Find Full Text PDFEffects of two continuous infusion doses of lidocaine on isoflurane minimum anesthetic concentration in chickens.
Vet Anaesth Analg
January 2023
Department of Clinical Sciences, Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis, West Indies.
Objective: To assess the effect of two intravenous (IV) doses of lidocaine on the minimum anesthetic concentration (MAC) of isoflurane in chickens.
Study Design: Blinded, prospective, randomized, experimental crossover study.
Animals: A total of six adult female chickens weighing 1.
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