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Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019).
Elife
January 2025
Department of Social and Applied Nutrition, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
The role of circulating metabolites on child development is understudied. We investigated associations between children's serum metabolome and early childhood development (ECD). Untargeted metabolomics was performed on serum samples of 5,004 children aged 6-59 months, a subset of participants from the Brazilian National Survey on Child Nutrition (ENANI-2019).
View Article and Find Full Text PDFDevelopment of Lentiviral Packaging Cells and Scale Up of Production to Meet the Growing Demand in Cell and Gene Therapy.
Curr Gene Ther
January 2025
Research Group Medical Biotechnology & Bioengineering, TH Köln - University of Applied Sciences, Leverkusen, Germany.
Gamma-Retroviral (RVVs) and lentiviral vectors (LVVs) represent indispensable tools in somatic gene therapy, mediating the efficient, stable transfer of therapeutic genes into a variety of human target cells. LVVs, in contrast to RVVs, are capable of stably genetically modifying non-proliferating target cells, making them the superior instrument in cell and gene therapy. To date, the LVV manufacturing process employs human embryonic kidney cells (HEK293) and derivatives thereof transiently transfected with multiple plasmids encoding the required viral vector components.
View Article and Find Full Text PDF[Trieste, free port - Football therapy with psychiatric patients. For the 100th anniversary of Franco Basaglia's birth].
Psychiatr Hung
January 2025
PTE Demográfia és Szociológia Doktori Iskola Addiktológia és Egészségmagatartás Program, Pécs, Hungary, E-mail:
Franco Basaglia's work is the cornerstone of the radical psychiatric movement in Italy. This culminated in the "Basaglia Law" of 1978, which aimed to abolish closed psychiatric institutions. In addition to becoming a symbolic place of movement, Trieste is still trying to preserve and put into practice the Basaglian tradition.
View Article and Find Full Text PDF[Diagnostics and treatment of autism spectrum disorder in adulthood].
Psychiatr Hung
January 2025
Semmelweis Egyetem ÁOK Pszichiátriai és Pszichoterápiás Klinika, Budapest, Hungary, E-mail:
Autism spectrum disorder is a neurodevelopmental condition with unique characteristics of perception and neurocognition that begins in childhood and persists into adulthood. It significantly affects social integration and adaptation, and is a great challenge in terms of psychological coping. Intensive genetic and neurobiological research is focused at understanding the brain underpinnings of autism, and it is also at the forefront of pharmacological development.
View Article and Find Full Text PDF[Introduction of the Low and Medium Security Psychiatry Unit at the Nyírô Gyula National Institute of Psychiatry and Addictology].
Psychiatr Hung
January 2025
Országos Pszichiátriai és Addiktológiai Intézet, Budapest, Hungary, E-mail:
Under the direction of the National Directorate General for Hospitals, and based on British examples and methodology, a new inpatient psychiatric ward with a high security level started operating at the National Institute of Psychiatry and Addictology in October 2023. As a new, independent unit, the High Security Psychiatry is a niche in Hungarian psychiatric care. The aim of the project was to reduce the burden on the whole mental health care system in Hungary, to increase public confidence in care and the safety of society through organizing of a specialised care team operating in an appropriate infrastructural environment.
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