Effects of single and repeated exposure of mice, rats, and rabbits in magnetic fields at 50 Hz and 2 kA/m, 16 kA/m, and 32 kA/m on the populations of dermal, intestinal, and popliteal lymph node labrocytes were studied immediately and within one month after exposure. Single exposure in the magnetic fields of 2 kA/m and 16 kA/m for 4 hours did not produce any changes in labrocytes of these organs. Repeated exposure to 2 kA/m, 16 kA/m, and 32 kA/m for 4 hours during 5 days modulated the functional activity of labrocytes in all the organs. More extended (1.5-2 months) repeated exposure to the intensive magnetic field (32 kA/m) stimulated adaptation and regain of labrocyte populations in the dermal and popliteal lymph nodes whereas enhanced secretion, i.e. degranulation of labrocytes persisted in the intestine. Following one month after the 1.5-2-month exposure to 32 kA/m, labrocyte populations were recovered with the maximum effect in the lymph nodes. High magnetic sensitivity of labrocytes revealed in this study can be used as a test of body reactivity and adaptation to this physical agent. Differences in the reactivity of labrocytes of individual organs and species must be taken into account.
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Invest Ophthalmol Vis Sci
December 2024
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.
Purpose: The purpose of this study was to identify serum metabolites associated with age-related macular degeneration (AMD) incidence and investigate whether metabolite profiles enhance AMD risk prediction.
Methods: In a prospective cohort study involving 240,317 UK Biobank participants, we assessed the associations of 168 metabolites with AMD incidence using Cox hazards models. Principal component analysis (PCA) captured 90% of the variance in metabolites.
Invest Ophthalmol Vis Sci
April 2023
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.
Purpose: This study aimed to assess the prevalence and characteristics of the peripapillary gamma zone in myopic, emmetropic, and hyperopic eyes of Chinese children.
Methods: Overall, 1274 children aged 6 to 8 years from the Hong Kong Children Eye Study underwent ocular examinations, including measurements of cycloplegic auto-refraction and axial length (AL). The optic disc was imaged using a Spectralis optical coherence tomography (OCT) unit and a protocol involving 24 equally spaced radial B-scans.
Ophthalmol Ther
April 2023
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong SAR, China.
Introduction: This study aimed to evaluate the habitual reading distance among non-myopic children and also myopic children with undercorrection and with full correction.
Methods: This was a population-based cross-sectional study with a total of 2363 children aged 6-8 years who were recruited from the Hong Kong Children Eye Study. Cycloplegic autorefraction, subjective refraction, habitual visual acuity, and best corrected visual acuity were measured.
Am J Ophthalmol
August 2022
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong (S.M.T., K.W.K., M.Y., L.J.C., A.L.Y., C.C.T., C.P.P., J.C.Y.), Hong Kong; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital (K.W.K., L.J.C., A.L.Y., C.C.T., J.C.Y.), Hong Kong;; Hong Kong Eye Hospital (C.C.T., J.C.Y.), Hong Kong.. Electronic address:
Br J Ophthalmol
September 2023
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
Background/aims: To identify normative values and determinants for Bruch's membrane opening (BMO) and the minimum rim width of BMO (BMO-MRW) among healthy children.
Methods: A population-based cross-sectional study from the Hong Kong Children Eye Study, recruiting 1, 226 children aged 6-8 years. Spherical refractive error, axial length (AL), body mass index and intraocular pressure (IOP) were measured.
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