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Similar Publications
Uncommon and Unusual Variants of Autoimmune Bullous Diseases.
Indian Dermatol Online J
August 2024
Department of Dermatology, Venereology and Leprology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Article Synopsis
- Autoimmune blistering diseases (AIBDs) are skin conditions caused by the body's immune system attacking certain proteins, leading to blister formation, and can be categorized into intraepidermal and subepidermal types.
- The objective of this review is to raise awareness about rare and uncommon AIBD variants, such as pemphigus herpetiformis and anti-laminin 332 pemphigoid, among others.
- By discussing these unusual variants, the review aims to assist healthcare professionals in the early diagnosis and treatment of these conditions.
Diagnosis of autoimmune bullous dermatoses: Comparative analysis of immunohistochemical staining using C4d, C3d, IgG, and IgG4 in lesional tissues and perilesional frozen skin samples.
Ann Diagn Pathol
December 2024
Tekirdağ Namık Kemal University Medical Faculty, Dermatology and Venereology Department, Tekirdağ, Turkey. Electronic address:
Article Synopsis
- Immunohistochemical staining using immunoglobulins and complements can help diagnose autoimmune bullous dermatoses (AIBD), particularly when combined with clinical and histological assessments.
- A study analyzed 136 biopsy cases suspected of AIBD over four years, confirming diagnoses through various methods, with 52 ultimately classified as AIBD.
- In lesional biopsies, certain markers (C4d, C3d, IgG, and IgG4) showed varying sensitivity and specificity for identifying pemphigoid and pemphigus diseases, with particularly high specificity noted in pemphigoid cases.
Re-evaluating the prevalence of anti-desmocollin-1 IgA autoantibodies in canine pemphigus foliaceus.
Vet Immunol Immunopathol
July 2024
North Caroline State University, College of Veterinary Medicine, Department of Clinical Sciences, 1060 William Moore Drive, Raleigh, NC 27607, USA. Electronic address:
Article Synopsis
- Pemphigus foliaceus (PF) is an autoimmune skin disease in dogs, marked by pustules and caused by IgG autoantibodies targeting desmocollin-1 (DSC1), which is crucial for skin cell adhesion.
- Previous research indicated that passive transfer of these autoantibodies can induce skin disease, but the recruitment of neutrophils remained unexplained.
- Our study aimed to clarify the role of IgA autoantibodies in PF, but after removing significant amounts of IgG from dog sera, we found no increase in IgA levels, suggesting that IgA does not play a pathogenic role in this condition.
Article Synopsis
- IgA pemphigus is an autoimmune disease characterized by the presence of IgA autoantibodies targeting keratinocyte cell surfaces, resulting in skin and, rarely, oral mucosal lesions.
- A 31-year-old woman exhibited skin erythema, pustules, and erosions in her mouth, with histopathology confirming acantholysis and neutrophil infiltration.
- While typical cases of IgA pemphigus have limited oral involvement, this case highlights the presence of oral lesions as a potential indicator of anti-desmoglein 3 IgA, suggesting a rare subtype of the disease.
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