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A Complex Case of Acute Liver Failure Following Idiosyncratic Drug-Induced Liver Injury, Potentiated by Herpes Simplex Virus Infection.
Cureus
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Internal Medicine, Unidade Local de Saúde de São José, Lisbon, PRT.
Acute liver failure (ALF) is a rare, life-threatening condition that may be secondary to drug-induced liver injury (DILI) and certain viral infections. We present the case of a 73-year-old male with a history of fibrotic hypersensitivity pneumonitis with a progressive phenotype, type 2 diabetes mellitus, hypertension, and hyperlipidemia, who was admitted with ALF potentially secondary to DILI. Prior to admission, he was receiving therapy that may be related to idiosyncratic DILI (I-DILI) and ALF, namely nintedanib, which appears to have a most probable relation to I-DILI in this case, considering it was the most recently started drug.
View Article and Find Full Text PDFA Unique Case of Metastatic Oral Kaposi Sarcoma in an HIV-Negative Patient.
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Department of Otolaryngology-Head & Neck Surgery, Lehigh Valley Health Network, Allentown, PA, USA.
Kaposi's sarcoma (KS) is a tumor involving blood vessels and lymphatic tissue. It is caused by human herpes virus-8, typically in HIV infection in individuals with AIDS. There are 4 major types of KS including classic, endemic, immunosuppression, and AIDS-related.
View Article and Find Full Text PDF[Viral-epigenetic hypothesis of Parkinson's disease etiopathogenesis.].
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January 2025
Bashkir State Medical University, 3 Lenin str., Ufa 450008, Russian Federation, e-mail:
Data accumulated in scientific literature indicate that Parkinson's disease develops after infections caused by SARS-CoV-2, West Nile, Coxsackie, St. Louis viruses, Japanese encephalitis B, hepatitis B and C, influenza A, HIV, herpes viruses, flaviviruses. Neuroinvasive West Nile viruses and HIV activate expression of alpha-synuclein.
View Article and Find Full Text PDFSociodemographic factors and comorbidities are associated with an elevated risk of herpes simplex keratitis: a population-based study in Taiwan.
Front Microbiol
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Department of Ophthalmology, Chi Mei Medical Center, Tainan, Taiwan.
To investigate the association among comorbidities, sociodemographic factors, and herpes simplex keratitis (HSK). This nationwide, population-based, retrospective, matched case-control study included 27,651 patients with HSK identified from the Taiwan National Health Insurance Research Database based on the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code 054.42 for dendritic keratitis and 054.
View Article and Find Full Text PDFUnderstanding the Interplay between oHSV and the Host Immune System: Implications for Therapeutic Oncolytic Virus Development.
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Department of Biology, College of Science and Technology, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA. Electronic address:
Oncolytic herpes simplex viruses (oHSV) preferentially replicate in cancer cells while inducing antitumor immunity, and thus, they are often referred to as in situ cancer vaccines. OHSV infection of tumors elicits diverse host immune responses comprising both innate and adaptive components. Although the innate/adaptive immune responses primarily target the tumor, they also contribute to antiviral immunity, limiting viral replication/oncolysis.
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