The traditional assessment of fracture healing by manipulation and viewing of radiographs is subjective and qualitative. Dual energy x-ray absorptiometry by contrast provides an accurate, precise, and minimally invasive quantitative measure of bone mineral density, a property that shows strong correlations with various mechanical properties of bone. Fourteen patients with unilateral tibial shaft fractures stabilized by external fixation were monitored with dual energy x-ray absorptiometry at monthly intervals after fracture. Fractured and contralateral unfractured bones (controls) were scanned on each occasion. Changes in mineralization with time over the whole length of the fractured bone could be seen. The most pronounced effects were visible in the area of the fracture, with a minimum recorded fracture site bone mineral density of 38 +/- 13% of contralateral values, but often more long term alterations in bone mineral density affected regions at some distance from this zone. Significantly, in four patients who had scans 5 or more months after fracture, the mineralization at the fracture site had returned to control levels, whereas bone mineral density in a region proximal to the fracture showed evidence of persisting posttraumatic osteoporosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00003086-199706000-00026 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A protein corona modulates the function of mineralization-competent matrix vesicles.
JBMR Plus
February 2025
Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14040-901, Brazil.
Mineralizing cells release a special class of extracellular vesicles known as matrix vesicles (MV), crucial for bone mineralization. Following their release, MV anchor to the extracellular matrix (ECM), where their highly specialized enzymatic machinery facilitates the formation of seed mineral within the MV's lumen, subsequently releasing it onto the ECM. However, how MV propagate mineral onto the collagenous ECM remains unclear.
View Article and Find Full Text PDFA novel application perspective of the clinical-used drug verapamil on osteoporosis via targeting .
J Orthop Translat
January 2025
Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China.
Background: RANKL and SCLEROSTIN antibodies have provided a strong effective choice for treating osteoporosis in the past years, which suggested novel molecular target identification and therapeutic strategies development are important for the treatment of osteoporosis. The therapeutic effect of verapamil, a drug previously used for cardiovascular diseases, on diabetes was due to the inhibition of TXNIP expression, which has also been reported as a target in mice osteoporosis. Whether verapamil-inhibited TXNIP expression is related to osteoporosis and how it works on the molecular level is worthy to be explored.
View Article and Find Full Text PDFCorrelation between 25-hydroxyvitamin D level of lactating mothers and bone mineral density of infants and analysis of risk factors.
J Med Biochem
November 2024
Maternal and Child Health Hospital of Hubei Province, Department of Child Health, Wuhan, Hubei Province, China.
Background: Aim was to demonstrate the influencing factors of infant bone mineral density (BMD) and its correlation with serum 25-hydroxyvitamin D (25-(OH)D) in nursing mothers.
Methods: 200 children aged 0 č 1 years were rolled into normal group (n=120) and abnormal group (n=80) regarding the results of ultrasound BMD examination. The sunshine duration of infants with different BMD and 25(OH)D, calcium and phosphorus levels of nursing mothers were analyzed, and univariate and multivariate analyses of BMD were implemented.
Dietary acidity and bone mass in minority children and adolescents: a cross-sectional analysis from the MetA-Bone trial.
Arch Osteoporos
January 2025
Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA.
Unlabelled: Dietary acid load could be associated with bone mass, but there are limited and conflicting results. This secondary cross-sectional analysis evaluated these associations among 123 children/adolescents, mostly Hispanics. Dietary acid load seems to be associated with bone mass in boys, but these results should be confirmed through long-term studies.
View Article and Find Full Text PDFAssociation of low-sodium salt intervention with osteoporosis: A cross-sectional study based on the SSaSS study.
Arch Osteoporos
January 2025
Department of Clinical Epidemiology and Evidence-Based Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Unlabelled: Low-sodium salt has a protective effect on BMD and also reduces the risk of osteopenia due to elevated blood glucose. This provides a direct and effective way to improve bone health in patients with hyperglycemia.
Objective: There is no consensus on the relationship between salt type and bone mineral density (BMD).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!