The psychomotor development of 171 preterm very-low-birthweight (VLBW) infants (birthweight < or = 1500 g) at 10 months of corrected age was assessed by the Griffiths' Mental Developmental Scale. The developmental score was related to the prenatal and obstetric risk factors and to the neonatal health status of each infant. These results, in turn, were compared to findings for a reference group of full-term infants. This analysis revealed that prolonged ventilator treatment, patent ductus arteriosus, bronchopulmonary dysplasia, brain haemorrhage with ventricle dilatation, white matter lesions, low birthweight and low gestational age influenced psychomotor development in an unfavourable manner. Multiple regression analysis confirmed most of these correlations. Preterm birth per se (when children with risk factors were excluded) in general had no significant effect on psychomotor development. However, the early development of preterm infants with several neonatal risk factors was adversely affected.
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