The authors have developed the optimal variant of the enzyme immunoassay system that contains plague murine monoclonal and equine polyclonal immunoglobulins and identified all plague microbe strains at a high sensitivity (3.84 m.cl/ml). The cross reactivity of monoclonal antibodies with some pseudotuberculosis agent strains does not prevent from using the developed test system for laboratory diagnosis of plague, particularly while isolating atypical (capsule- or plasmid-free) variants of Y. pestis, taking into account parallel special diagnostic tests for pseudotuberculosis.
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