Tripeptide methylketones: synthesis and antiplasmin activity.

Farmaco

Instytut Chemii, Uniwersytet Warszawski Filia w Białymstoku, Białystok, Poland.

Published: January 1997

A series of tripeptide methylketones with C-terminal lysine was obtained via Dakin-West method and tested for their antiplasmin activity with the use of antifibrinolytic and antiamidolytic tests. The tripeptide methylketones has been found to inhibit plasmin, however with much lower potency than respective aldehydes.

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