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Effective Treatment of Basal Cell Carcinoma with a Topical Enzymatic Mixture Enriched in Bromelain: Summary of Proof-Of Concept Clinical Studies on the First 22 Tumors.
J Clin Med
November 2024
Department of Emergency Medicine, Renaissance School of Medicine, Stony Brook University, HSC-L4-080, Stony Brook, NY 11794-8350, USA.
Basal cell carcinoma (BCC), the most prevalent form of human cancer, is traditionally treated by surgical and alternative destructive or topical chemical means, each with its advantages, challenges, and drawbacks. We describe our experience treating BCCs with a topical concentrate of proteolytic enzymes enriched in bromelain (CPEEB) sourced from pineapple stems. CPEEB has strong proteolytic, antitumor-proapoptotic, and inflammation modulation activities, and is approved for debridement of deep burns and starting phase 3 trials for chronic wounds.
View Article and Find Full Text PDFErosive Tarsal Conjunctival Lesions Following Immunogenic Events in Early Development of Ocular Graft-vs-Host Disease.
Life (Basel)
October 2024
Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Purpose: Ocular graft-versus-host disease (oGVHD) affects more than half of the patients following allogeneic hematopoietic stem cell transplantation (HSCT). The disease onset and the pathogenesis of oGVHD are not well understood. We hope to identify the triggers and explore the clinical signs and symptoms of oGVHD development at the early stages.
View Article and Find Full Text PDFLeukemia cutis as a prominent clinical sign in a dog with acute myeloid leukemia.
Vet Clin Pathol
December 2024
Department of Clinical Sciences and Services, Royal Veterinary College, Hatfield, Hertfordshire, UK.
Article Synopsis
- An eight-year-old neutered crossbreed dog presented with severe skin lesions and signs of systemic illness, leading to a thorough hematologic assessment.
- The tests revealed nonregenerative anemia, thrombocytopenia, and a high population of neoplastic mononuclear cells, ultimately diagnosing the dog with acute myeloid leukemia (AML).
- Despite findings of AML affecting multiple organs, the owner opted for euthanasia, marking this case as the first documented instance of ulcerative skin lesions linked to AML in a dog.
Factors Associated With Decision to Treat or Not to Treat Helicobacter pylori Infection in Children: Data From the EuroPedHp Registry.
Helicobacter
September 2024
Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital Munich, München, Germany.
Article Synopsis
- - The study analyzed treatment decisions for H. pylori infection in children using data from the EuroPedHp Registry, focusing on various factors influencing whether or not therapy was administered, especially regarding gastrointestinal (GI) comorbidities.
- - Out of 1165 pediatric patients, those with GI comorbidities were significantly less likely to receive eradication treatment (only 57%) compared to those with no comorbidities (89%) despite having similar symptoms and conditions.
- - The findings suggest that H. pylori-infected children with GI issues had a much lower chance (75% reduced) of receiving treatment, indicating no rationale for different management approaches based on GI comorbidities in pediatric patients with confirmed infections.
Combined eosinophilic gastroenteritis and ulcerative colitis successfully treated by vedolizumab: a case report.
Intest Res
August 2024
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Article Synopsis
- A 47-year-old man with a long history of ulcerative colitis experienced sudden acute epigastric pain, leading to a medical examination that revealed eosinophilic gastroenteritis.
- After initial treatment with steroids proved ineffective, the patient was given vedolizumab, which successfully alleviated his symptoms and showed significant improvement in both conditions during follow-up examinations.
- The study suggests that vedolizumab, known for treating ulcerative colitis, may also be a viable treatment option for eosinophilic gastroenteritis due to the shared mechanism of targeting eosinophils.
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