Sequential measures of granulomonocytic stem cell (CFUc) pool were undertaken during chemotherapy in a case of multiple myeloma. Whereas the number of blood granulocytes remained unchanged, the total number of CFUc was markedly decreased. Therefore the CFUc marrow pool can be considered as one of the data in the management of chemotherapy. In multiple myeloma, the tumour mass can be evaluated by the secretion of monoclonal lg. It appears possible to adapt the schedule of chemotherapy considering both its effect against the tumoral cells and its toxicity on bone marrow stem cells.
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