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Identification of pore-forming subunit of P-type calcium channels: an antisense study on rat cerebellar Purkinje cells in culture. | LitMetric
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Identification of pore-forming subunit of P-type calcium channels: an antisense study on rat cerebellar Purkinje cells in culture.

S E Gillard S G Volsen W Smith R E Beattie D Bleakman D Lodge

Neuropharmacology

Lilly Research Centre, Eli Lilly Co. Ltd., Windlesham, Surrey, U.K.

Published: March 1997

Treatment of cerebellar neurones in culture with an antisense oligonucleotide (ODN) against alpha1A, reduced the whole-cell P-type calcium channel current relative to mismatch ODN treated controls (p < 0.001). Therefore, AgaIVA (50 nM) reduced whole-cell calcium current in mismatch and antisense treated cells by 70 +/- 4 and 19 +/- 3%, respectively.

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http://dx.doi.org/10.1016/s0028-3908(97)00046-4DOI Listing

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