Infusion of six concentrations of the dopamine uptake inhibitor bupropion into the neostriatum increased extracellular dopamine in a dose-dependent manner in 5-day-old and adult rats. There was no age-related difference when calculated as a percentage of predrug dopamine baseline levels, but the absolute increase of dopamine was greater in the adult rats. Bupropion had only a minor effect on extracellular levels of DOPAC.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0165-3806(97)00006-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Adolescent stress avoidance influences cue-induced heroin seeking and chaperonin gene expression in the dorsal striatum of adult female rats.
Am J Drug Alcohol Abuse
March 2025
Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Females remain underrepresented in opioid use disorder (OUD) research, particularly regarding dorsal striatal neuroadaptations. Chaperonins seem to play a role in opioid-induced neural plasticity, yet their contribution to OUD-related changes in the dorsal striatum (DS) remains poorly understood. Given known sex differences in opioid sensitivity, it is important to determine how chaperonin expression contributes to OUD-related adaptations in females.
View Article and Find Full Text PDFUnveiling the neuroprotective potential of Ipomoea carnea ethanol extract via the modulation of tau and β-secretase pathways in AlCl-induced memory impairment in rats in relation to its phytochemical profiling.
Inflammopharmacology
March 2025
Chemistry of Natural Compounds Department, National Research Centre, 33 El Bohouth St, Dokki, Giza, 12622, Egypt.
Alzheimer's disease (AD) is a widespread condition that affects adults and the community considerably. The causes are yet unknown, except from advanced age and genetic predisposition. Natural products provided advantageous advantages for managing AD due to their efficacy, safety, and accessibility.
View Article and Find Full Text PDFTalaromyces Marneffei infections in five human immunodeficiency virus-negative patients with the history of predation on wild bamboo rats (Rhizomys spp) - a case series.
BMC Infect Dis
March 2025
Cancer Center, Department of Pulmonary and Critical Care Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
Background: Talaromycosis is an aggressive and life-threatening disease, caused by the pathogen Talaromyces marneffei (T. marneffei) which was first isolated from the bamboo rats (Rhizomys sinensis). T.
View Article and Find Full Text PDFStructure and function relationships of mucociliary clearance in human and rat airways.
Nat Commun
March 2025
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Hastings Center for Pulmonary Research, University of Southern California, Los Angeles, CA, USA.
Mucociliary clearance is a vital defense mechanism of the human airways, protecting against harmful particles and infections. When this process fails, it contributes to respiratory diseases like chronic obstructive pulmonary disease (COPD) and asthma. While advances in single-cell transcriptomics have revealed the complexity of airway composition, much of what we know about how airway structure impacts clearance relies on animal studies.
View Article and Find Full Text PDFIntroduction: One of well-known exogenous fluorinated glucocorticoid that is used to treat inflammatory and various autoimmune illnesses is dexamethasone. Dexamethasone is known to cause skeletal muscular weakness and when used for an extended period of time, skeletal muscle undergoes atrophy. Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein that helps mobilize stem cells from bone marrow into peripheral circulation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!