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Development of Chitosan-Polyacrylic Acid Complex Systems for Enhanced Oral Delivery of and Probiotics.
Drug Des Devel Ther
January 2025
Department of Pharmaceutical Sciences and Pharmaceutics, Faculty of Pharmacy, Applied Science Private University, Amman, 11937, Jordan.
Introduction: The beneficial effects of probiotics are encountered by their low viability in gastrointestinal conditions and their insufficient stability during manufacturing, throughut the gastrointestinal transit, and storage. Therefore, novel systems are highly required to improve probiotics delivery.
Methods: In this study, Lactobacillus gasseri (L), Bifidobacterium bifidum (B), and a combination of L+B were encapsulated in chitosan (CS)-polyacrylic acid (PAA) complex systems (CS-PAA).
Emerging Microfluidic Building Blocks for Cultured Meat Construction.
ACS Appl Mater Interfaces
January 2025
State Key Laboratory of Meat Quality Control and Cultured Meat Development, Key Laboratory of Meat Processing, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Cultured meat aims to produce meat mass by culturing cells and tissues based on the muscle regeneration mechanism, and is considered an alternative to raising and slaughtering livestock. Hydrogel building blocks are commonly used as substrates for cell culture in tissue engineering and cultured meat because of their high water content, biocompatibility, and similar three-dimensional (3D) environment to the cellular niche . With the characteristics of precise manipulation of fluids, microfluidics exhibits advantages in the fabrication of building blocks with different structures and components, which have been widely applied in tissue regeneration.
View Article and Find Full Text PDFMicrofluidic design and preparation of hydrogel microcapsules of Mesona chinensis polysaccharide: Characterization, pH-responsive behavior and gastrointestinal protection for Lactobacillus plantarum.
Int J Biol Macromol
January 2025
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address:
Probiotics have brought many health benefits to the human body. However, their viability during gastrointestinal transit is a concern. Therefore, this study selected Mesona chinensis polysaccharide (MCP), an edible natural polysaccharide, and constructed a new type of microcapsules using MCP as raw material to prepare cross-linked calcium ions through a microfluidic system as an ideal intestinal targeting carrier to achieve precise delivery of bioactive substances.
View Article and Find Full Text PDFA design of Tetrastigma hemsleyanum's flavonoid loaded polyvinylpyrrolidone nanoparticles for improving its bioavailability and biological activities.
Food Chem
January 2025
School of Biological and Chemical Engineering, NingboTech University, 315100 Ningbo, China. Electronic address:
Flavonoids in plant extracts exhibit significant biological activities but are limited by their low bioavailability. This research aimed to improve the functional properties by synthesizing polyvinylpyrrolidone (PVP) nanoparticles using flavonoids derived from T. hemsleyanum.
View Article and Find Full Text PDFApplication of UPWr_E124 phage cocktail for effective reduction of avian pathogenic Escherichia coli in mice and broiler chickens.
Vet Microbiol
January 2025
Department of Biotechnology and Food Microbiology, Faculty of Biotechnology and Food Sciences, Wrocław University of Environmental and Life Sciences, 37 Chełmońskiego St., Wrocław 51-630, Poland. Electronic address:
Avian pathogenic Escherichia coli (APEC) is the main causative agent of colibacillosis, causing poultry respiratory infections, mortality and economic loss. APEC poses a serious threat to public health and food safety due to its multi-drug resistance and capacity to form biofilms. Bacteriophages (phages) have emerged as an alternative to antibiotics.
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