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The distribution of the alpha 7 nicotinic receptor subunit in the rat cerebellum was studied immunohistochemically at the electron microscope level using an alpha 7 subunit-specific antibody. The granule cell layer showed a much lower level of immunoreactivity for the alpha 7 subunit than the Purkinje cell layer. Granule cell somata were completely devoid of labeling; this appeared to be restricted to glomeruli exclusively located in the membranes of granule cell dendrites. The alpha 7 immunolabeling was located not at active synaptic areas but was mostly perisynaptic. This localization suggests that nicotinic receptors containing the alpha 7 subunit could have a modulatory function and/or play a direct role in the generation of synaptic currents.
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| http://dx.doi.org/10.1097/00001756-199704140-00021 | DOI Listing |
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