Glutathione S-transferases (GSTs) are a family of multifunctional enzymes involved in the metabolism of xenobiotics and reactive endogenous compounds. The interest in plant GSTs may be attributed to their agronomic value, since it has been demonstrated that glutathione conjugation for a variety of herbicides is the major resistance and selectivity factor in plants. The structure of the Arabidopsis thaliana isoenzyme, the first plant GST whose structure has been solved, may serve as a model system for the understanding of herbicide selectivity in crops.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Fungal endophytes modulate the negative effects induced by Persistent Organic Pollutants in the antarctic plant Colobanthus quitensis.
Physiol Plant
January 2025
Centro de Ecología Integrativa (CEI), Universidad de Talca, Talca, Chile.
Antarctica has one of the most sensitive ecosystems to the negative effects of Persistent Organic Pollutants (POPs) on its biodiversity. This is because of the lower temperatures and the persistence of POPs that promote their accumulation or even biomagnification. However, the impact of POPs on vascular plants is unknown.
View Article and Find Full Text PDFDiscovery and Characterization of Two Selective Inhibitors for a Mu-Class Glutathione S-Transferase of 25 kDa from Using Computational and Bioinformatics Tools.
Biomolecules
December 2024
Departmento de Química, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City C.P. 09310, Mexico.
Glutathione S-transferases (GSTs) are promising pharmacological targets for developing antiparasitic agents against helminths, as they play a key role in detoxifying cytotoxic xenobiotics and managing oxidative stress. Inhibiting GST activity can compromise parasite viability. This study reports the successful identification of two selective inhibitors for the mu-class glutathione S-transferase of 25 kDa (Ts25GST) from , named and , using a computationally guided approach.
View Article and Find Full Text PDFInvestigation of the Molecular Mechanism of Asthma in Meishan Pigs Using Multi-Omics Analysis.
Animals (Basel)
January 2025
Institute of Animal Husbandry and Veterinary Science, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China.
Asthma has been extensively studied in humans and animals, but the molecular mechanisms underlying asthma in Meishan pigs, a breed with distinct genetic and physiological characteristics, remain elusive. Understanding these mechanisms could provide insights into veterinary medicine and human asthma research. We investigated asthma pathogenesis in Meishan pigs through transcriptomic and metabolomic analyses of blood samples taken during autumn and winter.
View Article and Find Full Text PDFMetabolic resistance to pyrethroids with possible involvement of non-coding ribonucleic acids in Anopheles funestus, the major malaria vector in western Kenya.
BMC Genomics
January 2025
Program in Public Health, College of Health Sciences, University of California, Irvine, California, USA.
Background: The resurgence of Anopheles funestus, a dominant vector of human malaria in western Kenya was partly attributed to insecticide resistance. However, evidence on the molecular basis of pyrethroid resistance in western Kenya is limited. Here, we reported metabolic resistance mechanisms and demonstrated that multiple non-coding Ribonucleic Acids (ncRNAs) could play a potential role in An.
View Article and Find Full Text PDFResponses of biological characteristics and detoxification enzymes in the fall armyworm to methoxyfenozide stress.
J Econ Entomol
January 2025
Hubei Engineering Technology Center of Forewarning and Management of Agricultural and Forestry Pests, Yangtze University, Jingzhou 434000, PR China.
Methoxyfenozide is an insecticide with a unique mode of action on the insect ecdysone receptor and has been registered for the control of insect pests all over the world. In the present work, Spodoptera frugiperda was exposed to sublethal and lethal concentrations of methoxyfenozide to determine its impact on specific biological traits, metabolic enzyme activity, and the expression of detoxification enzymes. The result showed that 72-h posttreatment with LC50 and LC70 of methoxyfenozide significantly reduced the fecundity (eggs/female) of the F0 generation compared to those of the control group.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!