A hypnotic effect of chalcion (triazolam) was studied in 24 outpatients suffering from insomnia. It was found high and beneficial in pre-, intra- and post-insomniac disorders. Side effects were mild. Characteristics of chalcion-induced sleep reached to those of physiological sleep. Chalcion was found superior to other drugs used against insomnia.
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Predicting Food-Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling.
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October 2024
School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310058, China.
Piperine has been reported to inhibit the enzyme activity of cytochrome P450 (CYP) 3A4. The aim of this study was to develop and validate a physiologically based pharmacokinetic (PBPK) model for piperine and to predict potential food-drug interactions (FDIs) between piperine and CYP3A4 substrate drugs using these models. The PBPK model for piperine was successfully developed and validated.
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Center of Excellence in Drug Interaction Science, Certara USA, 4 Radnor Corporate Center, Suite 350, Radnor, PA 19087, USA.
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Article Synopsis
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