Autoptic findings of 120 patients with respiratory tuberculosis indicate that under the present-day conditions, the prevalent cause of death was a progressive tuberculous process as caseous pneumonia (89% of cases), which is much higher than our previous findings (42.9% in 1989 versus 66.% in 1994). Caseous pneumonia chiefly resulted from fibrous-cavernous tuberculosis, less frequently from an independent entity or manifestations of disseminated tuberculosis. Fibrous-cavernous tuberculosis, the major clinical form in the deceased, was frequently associated with specific involvement of intrathoracic lymph nodes (10.8% of cases) and also complicated by the hematogenic generalization of the process (6.7%) and specific pericarditis (5.0%). Progressive tuberculosis resulted in its later detection in a third of cases and irregular treatment in two thirds.
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J Drug Deliv Sci Technol
February 2025
Department of Chemical Engineering, University of Rhode Island, Kingston, RI 02881 USA.
Macrophages are an integral part of the innate immune system and act as a first line of defense to pathogens; however, macrophages can be reservoirs for pathogens to hide and replicate. Tuberculosis, influenza virus, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are common diseases whose pathogens are uptaken into macrophages. Current treatments for diseases such as these are limited by the therapeutic delivery method, which typically involves systemic delivery in large, frequent doses.
View Article and Find Full Text PDFCureus
December 2024
Radiology, Midland Metropolitan University Hospital, Birmingham, GBR.
Tuberculosis is a disease caused by (TB), demonstrating a vast clinical spectrum that can potentially involve all systems of the body. We present the case of a female in her late 20s, with an employment background in healthcare. She recently moved to the UK from India.
View Article and Find Full Text PDFFront Pharmacol
January 2025
State Key Laboratory of Respiratory Disease, Joint School of Life Sciences, Guangzhou Chest Hospital, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, China.
The efficacy of many compounds against is often limited when administered via conventional oral or injection routes due to suboptimal pharmacokinetic characteristics. Inhalation-based delivery methods have been investigated to achieve high local therapeutic doses in the lungs. However, previous models, typically employing wild-type strains, were intricate, time-consuming, labor-intensive, and with poor reproducibility.
View Article and Find Full Text PDFFront Public Health
January 2025
Gulf Center for Disease Control and Prevention (CDC), Riyadh, Saudi Arabia.
In January 2021, the Gulf Health Council (GHC), established the Gulf Centre for Disease Prevention and Control (Gulf CDC) in Riyadh, marking a pivotal step in harmonizing health strategies, enhancing knowledge generation, and promoting evidence-based approaches to both communicable (CD) and non-communicable diseases (NCD). The Gulf CDC's mission includes consolidating the region's health information systems, crucial for monitoring disease burden and shaping effective public health policies. An initial assessment of public health surveillance systems across the Gulf Cooperation Council (GCC) member states was conducted by the Gulf CDC.
View Article and Find Full Text PDFInfect Drug Resist
January 2025
Department of Tuberculosis, Beijing Chest Hospital, Capital Medical University, Beijing, People's Republic of China.
Background: Contezolid (CZD) is an analog of Linezolid (LZD) that has demonstrated potent in vitro and in vivo activity against tuberculosis (TB) while presenting a safer side-effect profile. In this study, we evaluated the early bactericidal activity (EBA) of CZD compared to LZD, with LZD serving as a control.
Methods: Naive, smear-positive pulmonary TB patients were enrolled and randomly assigned to receive either a 14-day monotherapy regimen of 600 mg LZD once daily (QD) or 800 mg CZD twice daily (BID).
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