Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1365-4362.1997.d01-492.xDOI Listing

Publication Analysis

Top Keywords

generalized epidermolytic
4
epidermolytic hyperkeratosis
4
hyperkeratosis child
4
child born
4
born parent
4
parent systematized
4
systematized epidermolytic
4
epidermolytic linear
4
linear epidermal
4
epidermal nevus
4

Similar Publications

Article Synopsis
  • * In rare cases, linear epidermal nevi can be passed down to children as epidermolytic ichthyosis, leading to severe skin symptoms at birth and ongoing skin issues.
  • * Cases of EHK transmission are more common when multiple body areas are affected by epidermal nevi, indicating a higher genetic risk, thus a genetics consultation is advised for affected individuals.
View Article and Find Full Text PDF
Article Synopsis
  • The epidermis protects the body and heals injuries through a complex keratinization process that involves the shedding of dead skin cells known as desquamation.
  • Keratinocyte differentiation is influenced by several factors including growth factors and changes in vitamin A and calcium levels, which help transform basal cells into fully differentiated corneocytes.
  • Skin keratinization disorders can lead to various dermatological diseases, categorized based on specific defects in keratin structure and the regulation of the keratinization process.
View Article and Find Full Text PDF

iRhoms are pseudoprotease members of the rhomboid-like superfamily and are cardinal regulators of inflammatory and growth factor signaling; they function primarily by recognizing transmembrane domains of their clients. Here, we report a mechanistically distinct nuclear function of iRhoms, showing that both human and mouse iRhom2 are non-canonical substrates of signal peptidase complex (SPC), the protease that removes signal peptides from secreted proteins. Cleavage of iRhom2 generates an N-terminal fragment that enters the nucleus and modifies the transcriptome, in part by binding C-terminal binding proteins (CtBPs).

View Article and Find Full Text PDF
Article Synopsis
  • Keratinopathic ichthyosis (KPI) is a genetic skin disorder caused by mutations in certain genes, and its symptoms can vary widely among individuals.
  • * A study involved 13 Chinese children with KPI, where DNA sequencing was used to identify specific gene mutations and their relation to clinical symptoms.
  • * The findings revealed that different types of mutations corresponded to distinct skin features, and suggested that oral acitretin may be a potential treatment for severe cases.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!