Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1046/j.1365-4362.1997.d01-492.x | DOI Listing |
Pediatr Dermatol
September 2024
Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Clin Exp Dermatol
May 2024
Department of Dermatology.
Int J Mol Sci
December 2023
Department of Dermatology and Venereology, General Hospital, 44000 Sisak, Croatia.
Mol Cell
January 2024
Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. Electronic address:
iRhoms are pseudoprotease members of the rhomboid-like superfamily and are cardinal regulators of inflammatory and growth factor signaling; they function primarily by recognizing transmembrane domains of their clients. Here, we report a mechanistically distinct nuclear function of iRhoms, showing that both human and mouse iRhom2 are non-canonical substrates of signal peptidase complex (SPC), the protease that removes signal peptides from secreted proteins. Cleavage of iRhom2 generates an N-terminal fragment that enters the nucleus and modifies the transcriptome, in part by binding C-terminal binding proteins (CtBPs).
View Article and Find Full Text PDFPediatr Investig
September 2023
Department of Dermatology, Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!