AI Article Synopsis
- The report discusses a case of hepatocellular carcinoma (HCC) characterized by extremely high plasma fibrinogen levels, reaching 1,704 mg/dl.
- Treatment for HCC led to a decrease in both plasma fibrinogen and PIVKA-II, an HCC marker, indicating a link between hyperfibrinogenemia and the cancer.
- The patient's HCC tissue samples showed strong reactions to human fibrinogen antiserum, suggesting that the cancer cells themselves were responsible for producing the elevated fibrinogen levels.
Article Abstract
The present report concerns a case of hepatocellular carcinoma (HCC) with marked hyperfibrinogenemia. The plasma fibrinogen level reached as high as 1,704 mg/dl. Since treatment against HCC resulted in reduction of plasma fibrinogen and PIVKA-II, an HCC marker, the hyperfibrinogenemia appears to be related to HCC. Immunohistochemically, the HCC specimen from this patient reacted strongly with antiserum to human fibrinogen, suggesting that the elevated fibrinogen was due to synthesis of this protein by the carcinoma cells, not to decreased fibrinolytic activity.
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| http://dx.doi.org/10.1159/000203691 | DOI Listing |
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