AI Article Synopsis
- - The study aimed to evaluate the variability of soft tissue measurements using dual energy X-ray absorptiometry (DXA) across different research institutions and configurations.
- - Conducted as a cross-sectional trial with five human subjects and four artificial phantoms, it involved duplicate DXA scans performed within a 15-day timeframe.
- - Findings showed low variability in total tissue mass but higher variability in fat and lean mass between sites, highlighting the importance of standardized calibration procedures for accurate soft tissue measurement in DXA.
Article Abstract
Objective: To assess intra- and inter-site soft tissue variability by dual energy X-ray absorptiometry (DXA).
Design: Cross-sectional trial.
Setting: Three medical research institutions.
Subjects: Five humans (in vivo) and four phantoms (in vitro), configured from two whole body phantoms with artificial skeletons and thickness overlays.
Interventions: Duplicate total-body DXA scans were performed on all subjects at each institution within a 15 d period.
Results: All intra-site coefficients of variation (CV) were < 0.5% for total tissue mass, but in vitro and in vivo Cvs were 7.2% and 2.3% for fat mass (FM) and 2.5% and 0.9% for lean mass (LM), respectively. Several total-body and regional FM and LM measurements were significantly different between sites (P < 0.05), with percent differences between sites ranging from 2.6-13.3% for FM and from 1.6-13.6% for LM. Site 2 was consistently lower for FM and Site 3 was consistently lower for LM.
Conclusions: These results stress the need for both rigorous and standardized cross-calibration procedures for soft tissue measurement by DXA.
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| http://dx.doi.org/10.1038/sj.ejcn.1600400 | DOI Listing |
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