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Pre-symptomatic scintigraphic and genetic cascade screening in cardiac transthyretin amyloidosis.
Eur J Nucl Med Mol Imaging
November 2024
Jagiellonian University Medical College, Department of Cardiac and Vascular Diseases, Institute of Cardiology, St. John Paul II Hospital, Pradnicka 80, 31-202, Krakow, Poland.
Purpose: While early diagnosis is crucial, as new treatments can significantly slow the progression of the disease, there is growing evidence on the application of novel imaging techniques for detecting transthyretin amyloidosis (ATTR) in pre-symptomatic stages. This study aimed to evaluate the utility of pre-symptomatic scintigraphic imaging cascade screening for early detection of ATTR.
Methods: During the period from 2020 to 2024, we conducted a prospective study that enrolled 100 consecutive adults.
The Utility of Baseline Characteristics and [I]MIBG Cardiac Adrenergic System Scintigraphy in Qualifying Patients with Post-Infarction Heart Failure for Implantable Cardioverter-Defibrillator (ICD) Placement.
J Clin Med
October 2024
Department of Congenital Heart Diseases, National Institute of Cardiology, 04-628 Warsaw, Poland.
Post-infarction heart failure with reduced ejection fraction (HFrEF) patients often face persistent risks of sudden cardiac arrest leading to sudden cardiac death. While implanting a cardioverter-defibrillator (ICD) can enhance prognosis, complications and costs limit its widespread use. Current patient qualification criteria, relying on imperfect parameters, require refinement.
View Article and Find Full Text PDFSolid versus liquid pulmonary micro-aspiration of reflux disease. Does it make a difference in determining the need for intervention?
Nucl Med Commun
January 2025
CNI Molecular Imaging.
Background: Pulmonary micro-aspiration (PMA) is a feared complication of gastroesophageal reflux disease (GORD). A novel scintigraphic test for GORD has been developed and validated. It can demonstrate contamination of the upper and lower airways by refluxate.
View Article and Find Full Text PDFEvaluation of pharmacokinetics, safety, and efficacy of [211At] meta-astatobenzylguanidine ([211At] MABG) in patients with pheochromocytoma or paraganglioma (PPGL): A study protocol.
PLoS One
May 2024
Advanced Research Center, Fukushima Global Medical Science Center, Fukushima Medical University, Fukushima, Japan.
Background: Pheochromocytoma, or paraganglioma (PPGL), is a tumor that arises from catecholamine-producing chromaffin cells of the adrenal medulla or paraganglion. Systemic therapy, such as the combination of cyclophosphamide, vincristine, and dacarbazine or therapeutic radiopharmaceuticals such as [131I] meta-iodobenzylguanidine (MIBG), may be administered in cases of locally advanced tumors or distant metastases. However, the current therapies are limited in terms of efficacy and implementation.
View Article and Find Full Text PDFBooster administration of Tc-99m PMT for delayed static imaging in patients with biliary atresia.
Ann Nucl Med
September 2024
Department of Radiology, Saitama Children's Medical Center, 1-2 Shintoshin Chuo-ku Saitama, Saitama, 330-8777, Japan.
Objective: Tc-99m N-pyridoxyl-5-methyl-tryptophan (PMT) hepatobiliary scintigraphy has high diagnostic performance for biliary atresia. Our hospital implements standard Tc-99m PMT administration followed by a 6 h static imaging review; booster doses are given in cases requiring 24 h delayed scans. This study aimed to evaluate the diagnostic performance of this method.
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