AI Article Synopsis
- Five new HLA-DRB1*08 alleles have been identified, but their prevalence in various populations is largely unstudied.
- Researchers used PCR-DNA typing to examine the Yucpa Amerindians in the Perijá Range, finding only the DRB1*0807 variant present at a frequency of 0.1250.
- Historically, the DRB1*0802 allele was most common among full-blooded Amerindians, but recent findings indicate the emergence of other variants like DRB1*0804 and DRB1*0811 in different South and North American tribes.
Article Abstract
Nucleotide sequences of five novel HLA-DRB1*08 alleles have been recently reported but their frequency in different populations is still unknown. The presence of DRB1*08 variants among Carib-speaking Yucpa Amerindians of the Perijá Range in the border between Colombia and Venezuela was tested by PCR-DNA typing. DRB1*0807 was the only DRB1*08 variant found in this population with a frequency of 0.1250. Until very recently, DRB1*0802 was the predominant DRB1*08 allele present among full-blooded Amerindians, but in the last 3 years DRB1*0804 has been found in 2 South American tribes and *0811 in 2 North American tribes. The description of a new functional DRB1*08 variant in Amerindians suggests that extensive gene polymorphism among Amerindians might not be limited to the HLA-B Class I locus.
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| http://dx.doi.org/10.1111/j.1399-0039.1997.tb02773.x | DOI Listing |
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