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Palmitoylcarnitine impairs immunity in decompensated cirrhosis.
JHEP Rep
November 2024
Biochemistry and Molecular Genetics Service, Hospital Clínic, IDIBAPS, Barcelona, Spain.
Background & Aims: In patients with cirrhosis, acute decompensation (AD) correlates with a hyperinflammatory state driven by mitochondrial dysfunction, which is a significant factor in the progression toward acute-on-chronic liver failure (ACLF). Elevated circulating levels of acylcarnitine, indicative of mitochondrial dysfunction, are predictors of mortality in ACLF patients. Our hypothesis posits that acylcarnitines not only act as biomarkers, but also actively exert detrimental effects on circulating immune cells.
View Article and Find Full Text PDFSirtuin 3 reinforces acylcarnitine metabolism and maintains thermogenesis in brown adipose tissue of aging mice.
Aging Cell
December 2024
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.
Acylcarnitine (ACar) is a novel fuel source for activating thermogenesis in brown adipose tissue (BAT). However, whether ACar metabolism underlies BAT thermogenesis decline with aging remain unclear. Here, the L-carnitine-treated young and aging mice were used to investigate the effects of activation of ACar metabolism on BAT thermogenesis during aging.
View Article and Find Full Text PDFBeneficial normalization of cardiac repolarization by carnitine in transgenic short QT syndrome type 1 rabbit models.
Cardiovasc Res
November 2024
Department of Cardiology and Angiology I, Medical Faculty, Heart Center University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany.
Article Synopsis
- Short-QT-syndrome type 1 (SQT1) is a heart condition caused by a genetic change that affects how the heart's electrical system works, leading to a higher risk of serious heart problems.
- In a study with rabbits that have SQT1, researchers found that giving them a substance called L-Carnitine helped lengthen the time it takes for the heart to reset after beating, which is a good thing for heart health.
- The study suggests that L-Carnitine works by improving the way certain electrical currents in the heart function, which might help people with this condition in the future.
Database screening as a strategy to identify endogenous candidate metabolites to probe and assess mitochondrial drug toxicity.
Sci Rep
December 2023
Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, 48104, USA.
Adverse drug reactions (ADRs) are considered an inherent risk of medication use, and some ADRs have been associated with off-target drug interactions with mitochondria. Metabolites that reflect mitochondrial function may help identify patients at risk of mitochondrial toxicity. We employed a database strategy to identify candidate mitochondrial metabolites that could be clinically useful to identify individuals at increased risk of mitochondrial-related ADRs.
View Article and Find Full Text PDFGinger essential oil and citral ameliorates atherosclerosis in ApoE mice by modulating trimethylamine-N-oxide and gut microbiota.
NPJ Sci Food
May 2023
Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ROC.
Recently, the role of the gut microbiota in diseases, including cardiovascular disease (CVD), has gained considerable research attention. Trimethylamine-N-oxide (TMAO), which is formed during ʟ-carnitine metabolism, promotes the formation of atherosclerotic plaques, causing thrombosis. Here, we elucidated the anti-atherosclerotic effect and mechanism of ginger (Zingiber officinale Roscoe) essential oil (GEO) and its bioactive compound citral in Gubra Amylin NASH (GAN) diet with ʟ-carnitine-induced atherosclerosis female ApoE mice.
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