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Effectiveness and safety of low-energy shock wave therapy for digital ulcers associated with systemic sclerosis: a phase 3 pivotal clinical trial.
Mod Rheumatol
November 2024
Department of Hematology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Objectives: Systemic sclerosis is characterised by ischaemic skin ulcers on the fingertips, and low-energy shock wave therapy is suggested as a novel treatment for ischaemic lesions with angiogenic effects. We aimed to investigate the efficacy and safety of shock wave therapy for skin ulcers in patients with systemic sclerosis.
Methods: In this phase 3 pivotal study, we analysed 60 systemic sclerosis patients with digital ulcers that did not disappear after >4 weeks of existing treatment: 30 patients were treated with extracorporeal shock wave therapy and 30 with conventional treatment.
Improvement of Post-sympathectomy Raynaud's Syndrome With Spinal Cord Stimulation.
Cureus
October 2024
Neurosurgery, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou Zhejiang, CHN.
Raynaud's phenomenon is a vascular disorder, characterized by vasospasm-induced discoloration, numbness, and pain in the extremities. While pharmacological treatments and sympathectomy are commonly employed, many patients experience symptom recurrence, and effective therapies for refractory cases remain limited. This case study presents a 60-year-old male with severe Raynaud's symptoms, including fingertip necrosis, unresponsive to pharmacotherapy and endoscopic thoracic sympathectomy.
View Article and Find Full Text PDFDigital ulcers associated with scleroderma: A major unmet medical need.
Wound Repair Regen
November 2024
College of Dentistry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Article Synopsis
- - Scleroderma (systemic sclerosis or SSc) often leads to painful digital ulcers (DUs), which significantly impact patients' quality of life and appear early in the disease.
- - While experts have defined digital ulcers, there's no consistent international agreement on this definition, complicating treatment approaches.
- - Current treatments primarily involve vasodilators due to their link with Raynaud's phenomenon, but many ulcers don’t respond, highlighting the urgent need for better understanding and new therapies for SSc-related wounds.
Primary Raynaud's Phenomenon of the Tongue.
Cureus
August 2024
Otolaryngology, Stony Brook University, New York, USA.
Article Synopsis
- Raynaud's phenomenon causes reduced blood flow in fingers and skin due to cold or stress, classified into primary and secondary forms, with the latter linked to various health issues.
- A clinical case of a 51-year-old male highlights the need for thorough evaluations to rule out serious conditions, showing the complexity of diagnosing Raynaud's.
- Management includes lifestyle changes and medications like calcium channel blockers, with advanced therapies available for severe cases, emphasizing the importance of personalized treatment for better outcomes.
Association between myeloid disorders and adult onset-inflammatory syndromes, successful treatment with JAK-inhibitors: Case series and literature review.
Leuk Res
November 2024
Leukemia and Myeloid Disorders, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, United States. Electronic address:
Article Synopsis
- * Recent findings link patients with mutations in the UBA1 gene to VEXAS syndrome, and a case-series highlights elderly patients showing inflammatory symptoms alongside myeloid disorders.
- * Treatment with JAK inhibitors, specifically upadacitinib and ruxolitinib, showed promise in improving symptoms and reducing reliance on corticosteroids, suggesting a need for larger studies to establish effective management strategies.
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