The participation of unsaturated (linoleic and arachidonic) and saturated (palmitic) fatty acids in reacylation of phosphatidylethanolamine (PE) in synaptosomes, photoreceptor membranes and erythrocytes at oxidative stress was studied. Induction of lipid peroxidation (LPO) was found to result in a significant decrease in the content of PE polyenoic fatty acids due to their oxidative destruction. It might be related to both an activation of phospholipase A2 and a decrease in PE reacylation rate. On contrary, under the same conditions an increase in incorporation of palmitic acid into PE was observed. The results of this study suggest that phospholipid deacylation-reacylation reactions comprise an important mechanism of both protection and adaptation of organisms to oxidative stress.
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