Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1235517 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Parallel labeled-line organization of sympathetic outflow for selective organ regulation in mice.
Nat Commun
December 2024
Laboratory for Comparative Connectomics, RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo, Japan.
The sympathetic nervous system is crucial for responding to environmental changes. This regulation is coordinated by the spinal sympathetic preganglionic neurons (SPNs), innervating both postganglionic neurons and the adrenal gland. Despite decades of research supporting the concept of selective control within this system, the neural circuit organization responsible for the output specificity remains poorly understood.
View Article and Find Full Text PDFRGS Proteins in Sympathetic Nervous System Regulation: Focus on Adrenal RGS4.
Front Biosci (Landmark Ed)
October 2024
Department of Pharmaceutical Sciences, Laboratory for the Study of Neurohormonal Control of the Circulation, Nova Southeastern University Barry and Judy Silverman College of Pharmacy, Davie/Fort Lauderdale, FL 33328-2018, USA.
Article Synopsis
- The sympathetic nervous system (SNS) includes neurons that release norepinephrine (NE) for local organ control and adrenal chromaffin cells that secrete epinephrine (Epi) into the bloodstream for broader physiological effects.
- G protein-coupled receptors (GPCRs) and Regulator of G protein Signaling (RGS) proteins, particularly RGS4, play crucial roles in modulating NE release and catecholamine secretion.
- Recent studies suggest that manipulating RGS4 may offer new treatments for conditions like heart failure and hypertension, where SNS activity is disrupted.
Higher Steroid Production in the Right Adrenal Gland Compared to the Left One in db/db Mice, a Model of Type 2 Diabetic Obesity.
Int J Mol Sci
October 2024
Laboratory of Molecular Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Vertebrates exhibit a left-right asymmetry from the central structures to the peripheral paired endocrine organs. However, the asymmetries in paired endocrine glands and the pathological consequences of such asymmetries remain largely unknown. The adrenal gland constitutes a pair of peripheral end organs in the neuroendocrine system, responsible for producing steroid hormones under stimuli.
View Article and Find Full Text PDFWhat is the Vagal-Adrenal Axis?
J Comp Neurol
July 2024
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
Some recent publications have used the term "vagal-adrenal axis" to account for mechanisms involved in the regulation of inflammation by electroacupuncture. This concept proposes that efferent parasympathetic nerve fibers in the vagus directly innervate the adrenal glands to influence catecholamine secretion. Here, we discuss evidence for anatomical and functional links between the vagi and adrenal glands that may be relevant in the context of inflammation and its neural control by factors, including acupuncture.
View Article and Find Full Text PDFArticle Synopsis
- The study of adrenal disorders focuses on the adrenal glands' unique structure and essential functions, which are vital for scientific research.
- This review discusses non-traditional animal models, such as ferrets, dogs, and spiny mice, for studying congenital adrenal hyperplasia, pointing out their benefits and drawbacks.
- It emphasizes that spiny mice share notable similarities with human adrenal glands, suggesting they could be valuable for future research in this area.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!