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A Multimodal Intervention to Reduce C. difficile Infections and Stool Testing.
Pediatrics
March 2024
Department of Pediatrics, University of Colorado, Aurora, Colorado.
Background And Objectives: The introduction of multiplex gastrointestinal panels at our institution resulted in increased Clostridioides difficile (C. difficile) detection and stool test utilization. We aimed to reduce hospital-onset C.
View Article and Find Full Text PDFAcquisition site-based remodelling of Clostridium perfringens- and Clostridioides difficile-related gut microbiota.
Comp Immunol Microbiol Infect Dis
November 2023
Centro de Investigaciones en Microbiología y Biotecnología -UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá 111221, Colombia. Electronic address:
Introduction: Clostridium perfringens is a gram-positive, anaerobic sporulating bacillus which can infect several hosts, thereby being considered the causative agent of many gut illnesses. Some studies have suggested that C. perfringens's virulence factors may negatively affect gut microbiota homeostasis by decreasing beneficial bacteria; however, studies have failed to evaluate the simultaneous presence of other pathogenic bacteria, such as C.
View Article and Find Full Text PDFDevelopment and clinical application of a rapid, visually interpretable polymerase spiral reaction for tcdB gene of Clostridioides difficile in fecal cultures.
FEMS Microbiol Lett
January 2023
Department of Hygienic Inspection, School of Public Health, Jilin University, 1163 Xinmin Street, Changchun 130021, China.
In the surveillance of outbreaks of Clostridioides difficile infection, the rapid detection and diagnosis of C. difficile remain a major challenge. Polymerase spiral reaction (PSR) is a nucleic acid amplification technique that uses mixed primers and the strand displacement activity of Bst DNA polymerase to achieve a pair of primers and a single enzyme in an isothermal environment.
View Article and Find Full Text PDFReducing Recurrence and Complications Related to Clostridioides difficile Infection: A Panel Discussion Summary.
Prof Case Manag
October 2022
Rebecca Perez, MSN, RN, CCM, is an experienced RN with a master's degree in nursing, is a Certified Case Manager, and a member of the Gamma Omega Chapter of Sigma Theta Tau International Nursing Honor Society and Capella University National Society of Leadership and Success. She is the author of numerous professional articles, the primary author for the Case Management Adherence Guide 2020, co-author of CMSA's Integrated Case Management: A manual for case managers by case managers , developer of the Integrated Case Management Training Program, and Master Trainer. She joined Parthenon Management Group in 2020 as the Senior Manager of Education and Strategic Partnerships for the Case Management Society of America.
Background: The Centers for Disease Control and Prevention identifies Clostridioides difficile infection (CDI) as an urgent threat to people and health care systems. CDI leads to high health care utilizations and results in significantly reduced quality of life for patients. The high burden of disease is seen across all health care settings, outside of the hospital, in the community, and in younger people.
View Article and Find Full Text PDFRole of Fecal Microbiota Transplantation in Reducing Clostridioides difficile Infection-Associated Morbidity and Mortality: A Systematic Review.
Cureus
August 2022
Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
is a gram-positive, anaerobic, spore-forming bacterium that produces toxins A and B, disrupting the intestinal brush border and resulting in severe diarrhea. The most common causes of infection include prolonged antibiotic use, proton pump inhibitors (PPIs), and long-term hospitalization resulting in complications such as pseudomembranous colitis and toxic megacolon. This systematic review aims to consider fecal microbiota transplantation (FMT) as an early treatment modality in infection to prevent complications and reduce related morbidity and mortality.
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