Hypertrophic osteopathy associated with an intrathoracic neoplasm was diagnosed in a 7.5-year-old spayed female White New Zealand rabbit. The rabbit was examined because it had a swollen foot and was anorectic. An intrapulmonary mass as well as periosteal proliferation in the tarsometatarsal region were observed on radiography. Histologic examination of necropsy specimens was used to confirm the diagnosis of hypertrophic osteopathy secondary to metastatic adenocarcinoma of the lungs. To the author's knowledge, hypertrophic osteopathy has not been reported in lagomorphs, but should be considered as a differential diagnosis in lame rabbits.
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