AI Article Synopsis
- A study involving 30 adult patients with hemorrhagic periodontitis assessed the effects of neopredin gel, which contains prednisolone, neomycin sulfate, and chlorhexidine, as an additive to traditional dental cleaning (scaling and root planing) over 90 days.
- Results showed that patients using neopredin had significant reductions in plaque buildup, inflammation, and bleeding in the gums by various measurement indices at days 14, 30, and 90, highlighting the effectiveness of the treatment.
- A notable decrease in periodontal pocket depth was recorded at day 30, although some signs of inflammation reappeared by day 90, suggesting that while neopredin is beneficial, ongoing care may
Article Abstract
Thirty hemorrhagic periodontitis adult patients completed a 90-day controlled clinical study to determine the clinical effects of the antiinflammatory preparation neopredin gel containing prednisolone, neomycin sulfate and chlorhexidine when used an adjunct to scaling and root planing. The results were evaluated using the Quigley-Hein plaque index, the Schour-Massler gingival bleeding index, the Svrakov-Pissarev gingival vital staining index, the Muleman-Son sulcus bleeding index and the percentage of bleeding on probing sites. Treatment with neopredin resulted in consistently lower values of the mean plaque index score, the gingival bleeding index score, the vital staining index score and the sulcus bleeding index score at days 14.30 and 90. A significant reduction in the mean pocket probing depth was observed at day 30. The first symptoms of recurrent gingival inflammation were noticed at day 90. Our results indicate that neopredin is effective in reducing supragingival plaque accumulation, gingival inflammation, bleeding on probing and periodontal pocket depth and these reductions are highly significant.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
RNAseq of peripheral blood mononucleated cells exposed to platelet-rich fibrin and enamel matrix derivatives.
Sci Rep
January 2025
Department of Oral Biology, University Clinic of Dentistry, Medical University of Vienna, Sensengasse 2a, 1090, Vienna, Austria.
Platelet-rich fibrin (PRF) and Enamel Matrix Derivatives (EMD) can support the local regenerative events in periodontal defects. There is reason to suggest that PRF and EMD exert part of their activity by targeting the blood-derived cells accumulating in the early wound healing blastema. However, the impact of PRF and EMD on blood cell response remains to be discovered.
View Article and Find Full Text PDFThe PerioGene North study reveals that periodontal inflammation and advanced jawbone loss in periodontitis associate with serum gingipain antibodies but not with systemic autoimmunity.
Front Immunol
January 2025
Department of Odontology, Section for Molecular Periodontology, Umeå University, Umeå, Sweden.
Introduction: Periodontitis is associated with rheumatoid arthritis (RA). One hypothesis posits that this connection arises from the formation of autoantibodies against citrullinated proteins (ACPA) in inflamed gums, possibly triggered by . We previously demonstrated an increased antibody response to arginine gingipains (anti-Rgp IgG), not only in individuals with severe periodontitis compared to controls, but in RA versus controls, with an association to ACPA.
View Article and Find Full Text PDFHorizontal platelet-rich fibrin versus advanced platelet-rich fibrin plus in gingival recession management.
Clin Adv Periodontics
January 2025
Department of Periodontics and Implantology, SRM Dental College and Hospital, Chennai, India.
Background: Newer generation platelet concentrates, such as advanced platelet-rich fibrin plus (A-PRF+) obtained following low-speed centrifugation concept and horizontal platelet-rich fibrin (H-PRF) obtained from swing out and bucket system, showed increased platelet entrapment and growth factor release in the in-vitro studies. This prospective study aimed to evaluate and compare the clinical outcomes of A-PRF+ and H-PRF membranes in the treatment of gingival recession defects. The objectives of this study were to compare the changes in the recession height (RH) and the mean root coverage percentage (MRC%) between and within the research groups.
View Article and Find Full Text PDFChewing-Activated TRPV4/PIEZO1--Zn Axes in a Rat Periodontal Complex.
J Dent Res
January 2025
Department of Preventive and Restorative Dental Sciences, School of Dentistry, University of California, San Francisco, CA, USA.
The upstream mechanobiological pathways that regulate the downstream mineralization rates in periodontal tissues are limitedly understood. Herein, we spatially colocalized and correlated compression and tension strain profiles with the expressions of mechanosensory ion channels (MS-ion) TRPV4 and PIEZO1, biometal zinc, mitochondrial function marker (), cell senescence indicator (), and oxygen status marker hypoxia-inducible factor-1α () in rats fed hard and soft foods. The observed zinc and related cellular homeostasis in vivo were ascertained by TRPV4 and PIEZO1 agonists and antagonists on human periodontal ligament fibroblasts ex vivo.
View Article and Find Full Text PDFLow folate biomarker concentrations are associated with increase the risk and severity of periodontitis in adults: A cross-sectional study based on the National Health and Nutrition Examination Survey 2009-2014.
Nutr Res
December 2024
College & Hospital of Stomatology, Anhui Medical University, Key Laboratory of Oral Diseases Research of Anhui Province, Hefei, China; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
We sought to test the hypothesis that adult folate biomarker concentrations are negatively associated with the risk and severity of periodontitis. Data were pooled from the National Health and Nutrition Examination Survey (NHANES) 2009 to 2014. A total of 9252 dentate adult subjects aged 30 years and older who received a periodontal examination and had complete folate biomarker data were included in the analysis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!