As many as 29 oncological patients with severe depression of hemopoiesis secondary to cytostatic therapy underwent transfusion of fetal liver cells (FLC) from human embryos in the 8-12 weeks stage of their development cryopreserved in 5% DMCO at -196 degrees C as to the method elaborated at the Institute of Problems in Cryobiology and Cryomedicine. A strong correlation was found between infusion of a certain FLC dose and rise in leucocyte counts, which rise occurred by day 13-16 (r = +0.846). A minimum FLC dose for the expected leucocyte count rise to be of the magnitude of 3.32.10(9)/1 appeared to be 10(9) cells. Transplantation had a beneficial effect on the immune status of the patients. There was not a single case of graft-versus-host reaction. The above method has been recommended for use in clinical settings.
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Presse Med
December 2024
Division of Pathology, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montréal, Canada.
Dalton Trans
July 2024
Department of Chemistry, College of Science, University of Jeddah, 21589 Jeddah, Saudi Arabia.
Heteroleptic metal complexes containing Cu, Co, and Zn, incorporating curcumin and a Schiff base ligand (L), were synthesized and characterized, and their antifungal activity was evaluated. Their antifungal activities were investigated individually and in combination with fluconazole. Utilizing various analytical techniques such as UV-Vis, FT-IR, NMR, ESI-MS, TGA-DTG, elemental analyses, conductance, and magnetic susceptibility measurements, complex C1 ([Cu(Cur)LCl(HO)]) was assigned a distorted octahedral geometry, while complexes C2 ([Co(Cur)LCl(HO)]) and C3 ([Zn(Cur)LCl(HO)]) were assigned octahedral geometries.
View Article and Find Full Text PDFAntioxidants (Basel)
May 2024
Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
Fluconazole (FLC) is extensively employed for the prophylaxis and treatment of invasive fungal infections (IFIs). However, the fungistatic nature of FLC renders pathogenic fungi capable of developing tolerance towards it. Consequently, converting FLC into a fungicidal agent using adjuvants assumes significance to circumvent FLC resistance and the perpetuation of fungal infections.
View Article and Find Full Text PDFJ Funct Biomater
May 2024
Department of Animal, Poultry, and Fish Production, Faculty of Agriculture, Damietta University, Damietta 34517, Egypt.
A () strain producing antimicrobial and anti-inflammatory biomolecules (mainly 1,4-Diaza-2,5-dioxobicyclo[4.3.0]nonanes and pyrazine-derivatives) was tested for its capacity to cure clinical endometritis in buffaloes compared to conventional antibiotic-based treatment.
View Article and Find Full Text PDFCureus
May 2024
Department of Medicine, King Khalid University Hospital, King Saud University, Riyadh, SAU.
Multiple myeloma (MM) remains an incurable hematologic cancer leading to damage to the bone marrow that causes destructive bone lesions in addition to many other effects. I am a patient with MM who has undergone treatment to date since the diagnosis of this disease in December 2019. This paper reviews the treatments and observations made throughout this period.
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