Rabies virus infection of cultured adult mouse dorsal root ganglion neurons.

Mem Inst Oswaldo Cruz

Laboratorio de Neurobiología, Instituto Nacional de Salud, Bogotá, Colombia.

Published: June 1997

AI Article Synopsis

  • An in vitro model demonstrates how adult dorsal root ganglion neurons can be infected by the rabies virus.
  • The infection shows a preference for neurons, with a higher percentage and severity of infection compared to non-neuronal cells, despite neurons being less common in the culture.
  • The neuritic branches of the infected neurons are also significantly impacted by the virus.

Article Abstract

An in vitro model of adult dorsal root ganglion neurons infection by rabies virus is described, Viral marked neurotropism is observed, and the percentage and the degree of infection of the neurons is higher than in non neuronal cells, even if neurons are the minority of the cells in the culture. The neuritic tree is also heavily infected by the virus.

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Source
http://dx.doi.org/10.1590/s0074-02761996000500014DOI Listing

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