We have isolated a novel TGF beta-like gene from Xenopus which is highly related to mouse nodal The gene, Xnr4, is expressed at the gastrula stage in the Spemann organizer and at later stages in the notochord and neural tube. Ectopic expression of Xnr4 can induce and dorsalize mesoderm. These studies suggest that Xnr4, along with other nodal-related genes (Xnr1-3), may participate in mesodermal patterning and possibly neural development.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1006/dbio.1997.8510 | DOI Listing |
Publication Analysis
Top Keywords
spemann organizer
8
xnr4
4
xnr4 xenopus
4
xenopus nodal-related
4
nodal-related gene
4
gene expressed
4
expressed spemann
4
organizer isolated
4
isolated novel
4
novel tgf
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!