AI Article Synopsis
- Cerebellar syndrome can occur after acute lithium toxicity, with studies showing damage to cerebellar neurons and spongelike changes.
- An animal model using rats revealed significant cerebellar white matter changes five hours after lithium chloride injection.
- Despite the observed cerebellar effects, levels of key neurotransmitter metabolites remained unchanged, indicating that dopamine and serotonin systems are not directly involved in this toxicity.
Article Abstract
Cerebellar syndrome has been described after acute lithium intoxication in human. Neuropathological studies have demonstrated neuronal loss and spongiosis in the cerebellum. We describe an animal model of acute lithium-induced cerebellar degeneration. Five hours following administration of lithium chloride (250 mg/kg, i.p.), the cerebellar white matter of seven rats out 14 exhibited extensive spongiform changes. Microdialysis study in the rat cerebellar cortex demonstrated basal concentrations of dopamine (DA), hydroxy-3-methoxyphenylacetic acid (HVA) and 5-hydroxy-3-indolacetic acid (5-HIAA). These metabolites were unaffected by acute lithium intoxication suggesting that the cerebellar toxicity is not due to a modification of dopaminergic or serotoninergic neurotransmission.
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| http://dx.doi.org/10.1016/s0304-3940(97)13461-9 | DOI Listing |
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