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[The effect of exercise on platelet-activating factor metabolism in the livers of rats fed high-fat diet].
Sheng Li Xue Bao
August 2024
College of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua 321004, China.
This paper aimed to investigate the effects of exercise on hepatic platelet-activating factor (PAF) metabolism in rats fed a high-fat diet. Thirty-two male Sprague-Dawley (SD) rats were divided into control group (C), high-fat diet group (H), exercise group (EC), and high-fat diet+exercise group (EH). Serum lipids, glucose, insulin and markers of hepatic injury after a 16-week dietary and/or exercise intervention (60 min/day, 6 times/week) were measured by biochemical analysis; liver lipidomic profiles were analyzed by liquid chromatograph-mass spectrometer (LC-MS).
View Article and Find Full Text PDFPlatelet-activating factor contracts guinea pig esophageal muscularis mucosae by stimulating extracellular Ca influx through diltiazem-insensitive Ca channels.
J Pharmacol Sci
April 2024
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Chiba, Funabashi-City, 274-8510, Japan.
Platelet-activating factor (PAF) is expected to increase esophageal motility. However, to the best of our knowledge, this has not been examined. Thus, we investigated the contractile effects of PAF on guinea pig (GP) esophageal muscularis mucosae (EMM) and the extracellular Ca influx pathways responsible.
View Article and Find Full Text PDFPlatelet-activating factor (PAF) strongly enhances contractile mechanical activities in guinea pig and mouse urinary bladder.
Sci Rep
February 2022
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba, 274-8510, Japan.
In this study, we investigated the effects of platelet-activating factor (PAF) on the basal tone and spontaneous contractile activities of guinea pig (GP) and mouse urinary bladder (UB) smooth muscle (UBSM) tissues to determine whether PAF could induce UBSM tissue contraction. In addition, we examined the mRNA expression of the PAF receptor, PAF-synthesizing enzyme (lysophosphatidylcholine acyltransferase, LPCAT), and PAF-degrading enzyme (PAF acetylhydrolase, PAF-AH) in GP and mouse UB tissues using RT-qPCR. PAF (10-10 M) strongly enhanced the basal tone and spontaneous contractile activities (amplitude and frequency) of GP and mouse UBSM tissues in a concentration-dependent manner.
View Article and Find Full Text PDFActivation of PAF-synthesizing enzymes in rat brain stem slices after LTP induction in the medial vestibular nuclei.
Neurochem Res
November 2002
Department of Internal Medicine, Section of Biochemistry and Human Physiology, University of Perugia, Italy.
LysoPAF acetyltransferase (lysoPAF-AT) and PAF-synthesizing phosphocholinetransferase (PAF-PCT) are the two enzymes which catalyze the final reactions for the synthesis of PAF. Their activities, assayed in the homogenate of rat brain stem slices and under their optimal conditions, increased 5 min after high frequency stimulation of vestibular afferents, inducing LTP in the medial vestibular nuclei. The activity of phosphatidylcholine-synthesizing phosphocholinetransferase, was not affected.
View Article and Find Full Text PDFProperties and regulation of microsomal PAF-synthesizing enzymes in rat brain cortex.
Neurochem Res
May 2000
Istituto di Biochimica e Chimica Medica, Università di Perugia, Italy.
Platelet-activating factor (PAF) is a phospholipid mediator of long-term potentiation, synaptic plasticity and memory formation as well as of the development of brain damage. In brain, PAF is synthesized by two distinct pathways but their relative contribution to its productions, in various physiological and pathological conditions, is not established. We have further investigated on the properties of the two enzymes that catalyze the last step of the de novo or remodeling pathways in rat brain microsomes, PAF-synthesizing phosphocholinetransferase (PAF-PCT) and lysoPAF acetyltransferase (lysoPAF-AT), respectively.
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