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Baseline Inflammation but not Exercise Modality Impacts Exercise-induced Kynurenine Pathway Modulation in Persons With Multiple Sclerosis: Secondary Results From a Randomized Controlled Trial.
Int J Tryptophan Res
November 2024
Division of Performance and Health (Sports Medicine), Institute for Sport and Sport Science, TU Dortmund University, Dortmund, Germany.
Background: The kynurenine pathway (KP) is an important hub in neuroimmune crosstalk that is dysregulated in persons with multiple sclerosis (pwMS) and modulated by exercise in a modality-specific manner.
Objectives: To compare changes in the KP metabolite profile of pwMS (1) following combined treatments including either high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT) during a 3-week multimodal rehabilitation, (2) to evaluate exercise response in relation to baseline systemic inflammation, and (3) to investigate associations of kynurenines with physical capacity and clinical outcomes.
Methods: For this secondary analysis of a randomized controlled trial, serum concentrations of kynurenines at baseline and after 3 weeks were determined using targeted metabolomics (LC-MS/MS).
An exploratory study of metabolomics in endogenous and cannabis-use-associated psychotic-like experiences in adolescence.
Transl Psychiatry
November 2024
Institute of Clinical Medicine, University of Eastern Finland, Yliopistonranta 1, FI-70210, Kuopio, Finland.
In adolescence, psychotic-like experiences (PLE) may indicate potential prodromal symptoms preceding the onset of psychosis. Metabolomic studies have shown promise in providing valuable insights into predicting psychosis with enhanced precision compared to conventional clinical features. This study investigated metabolomic alterations associated with PLE in 76 depressed adolescents aged 14-20 years.
View Article and Find Full Text PDFFaecal biomarkers in children with coeliac disease: A way forward?
Acta Paediatr
November 2024
Department of Pediatric Research, The Faculty of Medicine, University of Oslo, Oslo, Norway.
Aim: Novel markers to reflect the intestinal damage in coeliac disease are needed. We studied the potential of faecal and serum neopterin, and faecal myeloperoxidase, human β-defensin-2, and lipocalin-2 in a case-control study.
Methods: Data were collected from medical records and a biobank including newly diagnosed coeliac disease patients, potential coeliac disease patients and non-coeliac controls.
Article Synopsis
- Vitamin B deficiency can cause serious issues like neurological damage and anemia, and is linked to chronic diseases, yet current tests for it are not very reliable.
- Researchers used metabolomic profiling to analyze serum samples from individuals with low vitamin B levels and identified 77 metabolites, which revealed significant differences in certain compounds between control and deficient groups.
- They determined that the ratio of taurine to chenodeoxycholic acid could serve as a strong biomarker for predicting low vitamin B levels, supported by mouse model studies showing significant metabolic changes due to deficiency.
Macrophage Activation Syndrome in Coinciding Pandemics of Obesity and COVID-19: Worse than Bad.
Adv Exp Med Biol
September 2024
Faculty of Medicine, Department of General Surgery, Gazi University, Besevler, Ankara, Turkey.
Epigenetic changes have long-lasting impacts, which influence the epigenome and are maintained during cell division. Thus, human genome changes have required a very long timescale to become a major contributor to the current obesity pandemic. Whereas bidirectional effects of coronavirus disease 2019 (COVID-19) and obesity pandemics have given the opportunity to explore, how the viral microribonucleic acids (miRNAs) use the human's transcriptional machinery that regulate gene expression at a posttranscriptional level.
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