The relation between women's age and fertility, and the factors that influence the age at which couples desire to have their first child, were analysed in a national sample of women aged 25-49 years. A random sample of 8050 households in the Netherlands was approached. In these households, 3295 women between the ages of 25 and 49 years answered a short questionnaire about planning their first pregnancy and about fertility. Furthermore, sociodemographic data were gathered. There appeared to be almost no variation in cumulative pregnancy rate between age 20 and 28: between 65 and 70% at 6 months, just below 90% at 12 months and approximately 93% at 24 months. After the age of 33 years, the cumulative pregnancy rate at 6 months decreased. From the age of 28 years the cumulative pregnancy rate at 12 months and at 24 months decreased gradually, reaching 75 and 80% respectively, by the age of 35 years. The year of birth of the woman (the 'time' factor) was the most important factor influencing the age at which couples desired to have their first child. In addition, demographic factors, particularly a high level of education, a high professional level and a high level of family income, were associated with the desire to have the first child at a relatively late age.
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http://dx.doi.org/10.1093/humrep/12.3.623 | DOI Listing |
Detecting low birth weight is crucial for early identification of at-risk pregnancies which are associated with significant neonatal and maternal morbidity and mortality risks. This study presents an efficient and interpretable framework for unsupervised detection of low, very low, and extreme birth weights. While traditional approaches to managing class imbalance require labeled data, our study explores the use of unsupervised learning to detect anomalies indicative of low birth weight scenarios.
View Article and Find Full Text PDFBMJ
January 2025
State Key Laboratory of Reproductive Medicine and Offspring Health, Centre for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, China
Objective: To test the hypothesis that a freeze-all strategy would increase the chance of live birth compared with fresh embryo transfer in women with low prognosis for in vitro fertilisation (IVF) treatment.
Design: Pragmatic, multicentre, randomised controlled trial.
Setting: Nine academic fertility centres in China.
J Endocr Soc
January 2025
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.
Context: Worldwide, obesity remains one of the most challenging crises with children being one of the most susceptible populations. The effect of maternal stress during pregnancy on newborn body composition, measured by fat mass and lean mass has, not been extensively studied.
Objectives: We evaluated the association between perceived stress during late pregnancy and infant adiposity at 1 month and assessed effect modification by infant sex and preterm birth.
Reprod Biol Endocrinol
January 2025
Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University Third Hospital, Beijing, 100191, China.
Objective: To study the correlation between anti-Müllerian hormone levels and pregnancy outcomes after in vitro fertilization/intracytoplasmic sperm injection in women with polycystic ovary syndrome, which remains controversial.
Methods: This retrospective cohort study recruited 4,719 women with infertility and polycystic ovary syndrome aged 20-40 years who underwent treatment at the Reproductive Center of Peking University Third Hospital between February 2017 and June 2023. We divided the participants into three groups according to the 25th and 75th percentile cutoffs of serum anti-Müllerian hormone: low (≤ 4.
Int J Hyg Environ Health
January 2025
NHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, School of Public Health, Fudan University, Shanghai, 200237, China. Electronic address:
Background: Direct evidence linking ambient temperature to human fecundity is sparse. We aimed to evaluate the potential impact of ambient temperature on time to pregnancy (TTP) and identify the optimal temperature range for initiating conception attempts.
Methods: Our analysis included 576 927 couples from the Chinese National Free Preconception Health Examination Project (NFPHEP) in Yunnan Province, with a one-year follow-up post-enrollment.
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