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Determinants of perceived patient benefit in a longitudinal cohort study of patients with psoriasis and atopic dermatitis.
Sci Rep
January 2025
Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
The Dermatology Life Quality Index (DLQI) should be used to assess treatment success in psoriasis (PSO). However, the DLQI does not assess the importance and achievement of treatment goals. The Patient Benefit Index (PBI) is a questionnaire that takes both into account.
View Article and Find Full Text PDFUnderstanding immune system dysfunction and its context in mood disorders: psychoneuroimmunoendocrinology and clinical interventions.
Mil Med Res
December 2024
Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801, Alcalá de Henares, Spain.
Mood disorders include a set of psychiatric manifestations of increasing prevalence in our society, being mainly represented by major depressive disorder (MDD) and bipolar disorder (BD). The etiopathogenesis of mood disorders is extremely complex, with a wide spectrum of biological, psychological, and sociocultural factors being responsible for their appearance and development. In this sense, immune system dysfunction represents a key mechanism in the onset and pathophysiology of mood disorders, worsening mainly the central nervous system (neuroinflammation) and the periphery of the body (systemic inflammation).
View Article and Find Full Text PDFWhy PNI scientists need to engage in exploratory hypothesis-generating biomarker studies.
Brain Behav Immun Health
December 2024
University of Stavanger, Dept. of Social Studies, Stavanger, Norway.
Multi-omics research is developing rapidly, offering extensive sample analysis options and advanced statistical solutions to identify and understand complex networks of biomarkers. This review encourages groups in the psychoneuroimmunology field with limited experience in research to embrace these advances. Cross-sectional studies can leverage existing sample collections to provide unique information that complements longitudinal studies, providing insights into which biological systems may warrant further investigation and building fundamental mechanistic knowledge of biological networks.
View Article and Find Full Text PDFSkin-brain dialogue in auto-inflammatory diseases: A new route to biomarkers?
Brain Behav Immun Health
December 2024
Pôle Hospitalo-Universitaire Psychiatrie Paris 15, GHU Paris Psychiatrie et Neurosciences, Hôpital Sainte-Anne, Paris, France.
Autoinflammatory diseases (AID) are rare systemic inflammatory disorders due to monogenic or polygenic dysfunction of innate immunity. They affect many organs including the brain and the skin. The spectrum of these diseases has been rapidly expanding recently due to newly developed diagnostic tools.
View Article and Find Full Text PDFThe Role of Insulin Within the Socio-Psycho-Biological Framework in Type 2 Diabetes-A Perspective from Psychoneuroimmunology.
Biomedicines
November 2024
University Chair in Clinical Psychoneuroimmunology, Campus of Melilla, University of Granada and PNI Europe, 52004 Melilla, Spain.
The interplay between socio-psychological factors and biological systems is pivotal in defining human health and disease, particularly in chronic non-communicable diseases. Recent advancements in psychoneuroimmunology and mitochondrial psychobiology have emphasized the significance of psychological factors as critical determinants of disease onset, progression, recurrence, and severity. These insights align with evolutionary biology, psychology, and psychiatry, highlighting the inherent social nature of humans.
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