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Regulation of trophectoderm morphogenesis by small GTPase RHOA through HIPPO signaling-dependent and -independent mechanisms in mouse preimplantation development.
Differentiation
January 2025
Yanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, 96813, USA. Electronic address:
The trophectoderm (TE) is the first tissue to differentiate during the preimplantation development of the mammalian embryo. It forms the outer layer of the blastocyst and is responsible for generating the blastocoel, a fluid-filled cavity whose expansion is essential for successful hatching and implantation. Here, we investigated the role of the small GTPase RHOA in the morphogenesis of the TE, particularly its relationship with HIPPO signaling, using mouse embryos as a model.
View Article and Find Full Text PDFCombined irradiation by gamma-rays and carbon-12 nuclei caused hyperlocomotion and change in striatal metabolism of rats.
Life Sci Space Res (Amst)
February 2025
Institute for High Energy Physics named by A.A. Logunov of NRC "Kurchatov Institute", Protvino, Russia.
Exposure to ionizing radiation during manned deep space missions to Mars could lead to functional impairments of the central nervous system, which may compromise the success of the mission and affect the quality of life for returning astronauts. Along with radiation-induced changes in cognitive abilities and emotional status, the effects of increased motor activity were observed. The mechanisms behind these phenomena still remain unresolved.
View Article and Find Full Text PDFAnalysis and identification of potential biomarkers for dysfunctional uterine bleeding.
J Reprod Immunol
January 2025
Department of Chinese Medicine Rehabilitation, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 50001, China. Electronic address:
Clinical evidence increasingly suggests that traditional treatments for dysfunctional uterine bleeding (DUB) have limited success. In this study, blood samples from 10 DUB patients and 10 healthy controls were collected for transcriptome sequencing. Then, the differentially expressed genes (DEGs) were screened and crossed with the DUB-related module genes to obtain the target genes.
View Article and Find Full Text PDFAcfA Regulates the Virulence and Cell Envelope Stress Response of .
Microorganisms
December 2024
School of Food Science and Engineering, Shaanxi University of Science & Technology, No. 6 Xuefu Road, Xi'an 710021, China.
is a ubiquitous inhabitant of estuarine and marine environments that causes vibriosis in aquatic animals and food poisoning in humans. Accessory colonizing factor (ACF) is employed by to assist in the colonization and invasion of host cells leading to subsequent illnesses. In this work, Δ, an in-frame deletion mutant strain lacking the 4th to the 645th nucleotides of the open reading frame (ORF) of the gene, and the complementary strain were constructed to decipher the function of AcfA in .
View Article and Find Full Text PDFPositive resonance: Successful interpersonal emotion regulation facilitated relationship closeness by enhanced inter-brain synchronization.
Neuroimage
January 2025
Shanghai Key Laboratory of Mental Health and Psychological Crisis Intervention, School of Psychology and Cognitive Science, East China Normal University, Shanghai, 200062, China; Shanghai Changning Mental Health Center, Shanghai, 200335, China; Key Laboratory of Philosophy and Social Science of Anhui Province on Adolescent Mental Health and Crisis Intelligence Intervention, Hefei Normal University, Hefei, China. Electronic address:
Interpersonal emotion regulation (IER) refers to the dynamic process where a regulator employs specific strategies to alleviate a target's distress. It remains unclear whether successful IER could facilitate interpersonal relationship closeness (IRC). The present study aimed to explore whether successful IER, based on two typical strategies-cognitive reappraisal (CR) and expressive suppression (ES)-for down-regulating the target's negative emotions, could enhance IRC among friend dyads, and to identify the underlying neural correlates of this process using functional near-infrared spectroscopy system.
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