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Pediatric relapsed/refractory ALK+ anaplastic large cell lymphoma treatment and outcomes in the targeted drug era.
Blood Adv
January 2025
Stanford University School of Medicine, Stanford, California, United States.
Treatment options for patients with relapsed or refractory (R/R) anaplastic large cell lymphoma (ALCL) have increased in the era of targeted therapies such as brentuximab vedotin (BV) and Anaplastic Lymphoma Kinase (ALK) inhibitors. However, there is no standard treatment and limited published data evaluating their use. The goal of this retrospective study is to describe current real-world treatment and outcomes of pediatric, adolescent, and young adult patients with R/R ALK-positive ALCL.
View Article and Find Full Text PDFIdentifying the Structure of Two-Dimensional ACuO (A = Na, K, Cs) Film on Cu(111) with Atomic Resolution.
J Phys Chem Lett
January 2025
College of Chemistry, Key Laboratory of Theoretical and Computational Photochemistry, Beijing Normal University, Beijing 100875, China.
The deposition of alkali metals on oxide surfaces has garnered significant interest due to their critical role in enhancing various catalytic processes. However, the atomic-scale characterization of these structures remains elusive, owing to the complex and competing interactions among the oxygen, the alkali metals, and the metal atoms within the oxides. In this work, we grew alkali metals (Na, K, Cs) on the copper oxide films on the Cu(111) surface and found the formation of hexagonally ordered monolayer films.
View Article and Find Full Text PDFBuilding an Exemplary Team of Master's-Prepared Nurses to Support Magnet® Designation.
J Nurs Adm
February 2025
Author Affiliation: Director of Policy and Professional Development (Dr Pate) and Director of Nursing Excellence (Dr Rankin), Atrium Health Carolinas Medical Center, Charlotte, North Carolina.
Although hospitals successfully achieving Magnet® designation demonstrate a multitude of positive outcomes, initial certification and maintenance require support from a highly engaged team. Two healthcare facilities used a team of master's-prepared nurses including the clinical nurse specialist, clinical nurse leader, and nursing professional development practitioner to strengthen a culture of nursing excellence, resulting in a successful redesignation cycle and the need for nurse executives to evaluate supportive nursing roles in acute care settings.
View Article and Find Full Text PDFPhysical activity alleviated associations of oxidation capacity of the atmosphere with platelet-based inflammatory indicators: findings from the Henan Rural Cohort Study.
Environ Sci Process Impacts
January 2025
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, PR China.
: several adverse effects of ozone (O) and nitrogen dioxide (NO) are assessed using combined oxidant capacity (O) and redox-weighted oxidant capacity (Owtx) as surrogates. However, the associations of oxidant capacity (O and Owtx) with platelet-based inflammatory indicators and the potential modifying role of physical activity (PA) remain unclear. : 31 318 participants were selected from the baseline survey of the Henan Rural Cohort Study.
View Article and Find Full Text PDFEmpagliflozin Reduces High Glucose-Induced Cardiomyopathy in hiPSC-Derived Cardiomyocytes : Glucose-induced Lipotoxicity in hiPSC-Derived Cardiomyocytes.
Stem Cell Rev Rep
January 2025
Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Human-induced pluripotent stem cell (hiPSC) technology has been applied in pathogenesis studies, drug screening, tissue engineering, and stem cell therapy, and patient-specific hiPSC-derived cardiomyocytes (hiPSC-CMs) have shown promise in disease modeling, including diabetic cardiomyopathy. High glucose (HG) treatment induces lipotoxicity in hiPSC-CMs, as evidenced by changes in cell size, beating rate, calcium handling, and lipid accumulation. Empagliflozin, an SGLT2 inhibitor, effectively mitigates the hypertrophic changes, abnormal calcium handling, and contractility impairment induced by HG.
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